Evidence map›Paper›PMID 33649203›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2021

Evaluating the potential efficacy and limitations of a phage for joint antibiotic and phage therapy of

Brandon A Berryhill, Douglas L Huseby, Ingrid C McCall, Diarmaid Hughes, Bruce R Levin

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed.

  1. Trial
  2. Article
  3. Article
  4. Article
  5. The Joint Action of Bacteriophage and Antibiotics in the Treatment ofbioRxiv : the preprint server for biology · 2026
    Article
  6. Article
  7. Review
  8. Article
  9. The role of innate immunity, antibiotics, and bacteriophages in the course of bacterial infections and their treatment.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  10. Article
  11. Article
  12. Article
  13. Review
  14. Article
  15. Article
  16. Article
  17. Response ofFrontiers in microbiology · 2024
    Article
  18. Article
  19. Bacteriophage therapy: are we running before we have learned to walk?European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2023
    Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Brandon A BerryhillDepartment of Biology, Emory University, Atlanta, GA 30322.ORCID 0000-0003-3430-0901
Douglas L HusebyDepartment of Medical Biochemistry and Microbiology, Biomedical Center, Uppsala University, 751 23, Uppsala, Sweden.ORCID 0000-0001-9974-578X
Ingrid C McCallDepartment of Biology, Emory University, Atlanta, GA 30322.ORCID 0000-0003-2873-7701
Diarmaid HughesDepartment of Medical Biochemistry and Microbiology, Biomedical Center, Uppsala University, 751 23, Uppsala, Sweden.ORCID 0000-0002-7456-9182
Bruce R LevinDepartment of Biology, Emory University, Atlanta, GA 30322; blevin@emory.edu.ORCID 0000-0003-3600-2780

Funding

Theoretical and experimental strudy of the population and evolutionary dynamics oR01GM091875 · NIGMS · EMORY UNIVERSITY · PI LEVIN, BRUCE RICHARD · 2009 to 2017
$2.5M
Theoretical and Experimental Studies of the Population and Evolutionary Dynamics of Bacteria and Bacteriophage.R35GM136407 · NIGMS · EMORY UNIVERSITY · PI LEVIN, BRUCE RICHARD · 2020 to 2024
$2.0M
NIGMS NIH HHS R01 GM091875NIGMS NIH HHS R35 GM136407
6 · The paper itself

Abstract

In response to increasing frequencies of antibiotic-resistant pathogens, there has been a resurrection of interest in the use of bacteriophage to treat bacterial infections: phage therapy. Here we explore the potential of a seemingly ideal phage, PYO

Indexed as

Phage TherapyStaphylococcal InfectionsStaphylococcus aureusAnti-Bacterial AgentsStaphylococcus PhagesAnti-Bacterial Agentsphage therapypopulation dynamicsStaphylococcus aureus

Identifiers

PMID33649203
PMCPMC7958385

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.