Evidence map›Paper›PMID 33649200›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2021

NF-κB-induced R-loop accumulation and DNA damage select for nucleotide excision repair deficiencies in adult T cell leukemia.

Yunlong He, Nagesh Pasupala, Huijun Zhi, Batsuhk Dorjbal, Imran Hussain, Hsiu-Ming Shih, Sharmistha Bhattacharyya, Roopa Biswas, Milos Miljkovic, Oliver John Semmes and 3 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed
2.3field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 42 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Article
  5. Review
  6. Review
  7. Review
  8. Article
  9. R-loops: a key driver of inflammatory responses in cancer.Experimental & molecular medicine · 2025
    Review
  10. Viral oncogenesis in cancer: from mechanisms to therapeutics.Signal transduction and targeted therapy · 2025
    Review
  11. Article
  12. Review
  13. Mechanisms underlining R-loop biology and implications for human disease.Frontiers in cell and developmental biology · 2025
    Review
  14. Review
  15. Article
  16. Article
  17. Article
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 2 countries.

Yunlong HeDepartment of Microbiology and Immunology, Uniformed Services University of the Health Sciences, Bethesda, MD 20814.
Nagesh PasupalaDepartment of Microbiology and Immunology, Uniformed Services University of the Health Sciences, Bethesda, MD 20814.
Huijun ZhiDepartment of Microbiology and Immunology, Uniformed Services University of the Health Sciences, Bethesda, MD 20814.
Batsuhk DorjbalDepartment of Pharmacology and Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD 20814.
Imran HussainDepartment of Microbiology and Immunology, Uniformed Services University of the Health Sciences, Bethesda, MD 20814.
Hsiu-Ming ShihInstitute of Biomedical Sciences, Academia Sinica, Taipei 11529, Taiwan.
Sharmistha BhattacharyyaDepartment of Anatomy, Physiology, and Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD 20814.ORCID 0000-0002-4289-6218
Roopa BiswasDepartment of Anatomy, Physiology, and Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD 20814.
Milos MiljkovicCenter for Cancer Research, National Cancer Institute, NIH, Bethesda, MD 20892.ORCID 0000-0001-5848-6320
Oliver John SemmesDepartment of Microbiology and Molecular Cell Biology, Eastern Virginia Medical School, Norfolk, VA 23501.ORCID 0000-0001-9927-4869
Thomas A WaldmannCenter for Cancer Research, National Cancer Institute, NIH, Bethesda, MD 20892.ORCID 0000-0003-4500-6660
Andrew L SnowDepartment of Pharmacology and Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD 20814.ORCID 0000-0002-8728-6691
Chou-Zen GiamDepartment of Microbiology and Immunology, Uniformed Services University of the Health Sciences, Bethesda, MD 20814; chou-zen.giam@usuhs.edu.ORCID 0000-0001-9656-5097
Uniformed Services University of the Health Sciences · USNational Cancer Institute · USEastern Virginia Medical School · USNational Health Research Institutes · TW

Funding

Interleukin-15 Production for Treatment of Patients with Metastatic MalignancyZIBBC010906 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI WALDMANN, THOMAS · 2009 to 2022
$29.3M
HTLV-I TAX MEDIATED DEREGULATION OF CELL STATER01CA076595 · NCI · UNIVERSITY OF VIRGINIA CHARLOTTESVILLE · PI SEMMES, OLIVER JOHN · 1999 to 2016
$2.9M
Clonal Expansion of HTLV-1-Infected Cells and Adult T Cell LeukemiaR21CA216660 · NCI · HENRY M. JACKSON FDN FOR THE ADV MIL/MED · PI GIAM, CHOU-ZEN · 2018 to 2019
$364k
NCI NIH HHS R01 CA076595NCI NIH HHS R21 CA216660
6 · The paper itself

Abstract

Constitutive NF-κB activation (NF-κB

Indexed as

DNA DamageDNA RepairDNA, NeoplasmGene Products, taxHeLa CellsHumansHuman T-lymphotropic virus 1Leukemia-Lymphoma, Adult T-CellNeoplasm ProteinsNF-kappa BDNA, NeoplasmGene Products, taxNeoplasm ProteinsNF-kappa Btax protein, Human T-lymphotrophic virus 1adult T cell leukemiaDNA damageNF-κB activationR-looptranscription-coupled nucleotide excision repair

Identifiers

PMID33649200
PMCPMC7958262
OpenAlexW3134365770

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.