ArticleProceedings of the National Academy of Sciences of the United States of America2021
Cell cycle-dependent active stress drives epithelia remodeling.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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Who cites it
34 citing papers in PubMed.
- Cell division sets a universal flow geometry in cell layers.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Liquid crystal-like self-organization of glioblastoma is associated with consistent migration for high cell densities.Scientific reports · 2026Article
- Partial EMT Drives Persistent Collective Migration via Collision Guidance in Heterogeneous Populations.bioRxiv : the preprint server for biology · 2026Article
- Cell divisions both challenge and refine tissue boundaries in the Drosophila embryo.Development (Cambridge, England) · 2026Article
- Focal Adhesion and Cancer Cell Cycle-Associated Resistance.ACS omega · 2026Review
- Learning Epithelial Elasticity via Local Tension Remodeling.bioRxiv : the preprint server for biology · 2025Article
- Cell jamming transitions can affect regulatory protein gradients and prime evolutionary divergence.Journal of the Royal Society, Interface · 2025Article
- Dynamic forces drive cell and organ morphology changes during embryonic development.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Vertex models capturing subcellular scales in epithelial tissues.PLoS computational biology · 2025Review
- Prickle2 regulates apical junction remodeling and tissue fluidity during vertebrate neurulation.The Journal of cell biology · 2025Article
- Large-scale control over collective cell migration using light-activated epidermal growth factor receptors.Cell systems · 2025Article
- Fluidization and anomalous density fluctuations in 2D Voronoi cell tissues with pulsating activity.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- A minimal vertex model explains how the amnioserosa avoids fluidization duringProceedings of the National Academy of Sciences of the United States of America · 2025Article
- Confinement, Jamming, and Adhesion in Cancer Cells Dissociating from a Collectively Invading Strand.PRX life · 2025Article
- Mechanical state transitions in the regulation of tissue form and function.Nature reviews. Molecular cell biology · 2024Review
- Cellular Energy Cycle Mediates an Advection-Like Forward Cell Flow to Support Collective Invasion.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Large-scale control over collective cell migration using light-controlled epidermal growth factor receptors.bioRxiv : the preprint server for biology · 2024Article
- E-cadherin biomaterials reprogram collective cell migration and cell cycling by forcing homeostatic conditions.Cell reports · 2024Article
- Mechanical forces across compartments coordinate cell shape and fate transitions to generate tissue architecture.Nature cell biology · 2024Article
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Authors and funding
5 authors.
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Abstract
Epithelia have distinct cellular architectures which are established in development, reestablished after wounding, and maintained during tissue homeostasis despite cell turnover and mechanical perturbations. In turn, cell shape also controls tissue function as a regulator of cell differentiation, proliferation, and motility. Here, we investigate cell shape changes in a model epithelial monolayer. After the onset of confluence, cells continue to proliferate and change shape over time, eventually leading to a final architecture characterized by arrested motion and more regular cell shapes. Such monolayer remodeling is robust, with qualitatively similar evolution in cell shape and dynamics observed across disparate perturbations. Here, we quantify differences in monolayer remodeling guided by the active vertex model to identify underlying order parameters controlling epithelial architecture. When monolayers are formed atop an extracellular matrix with varied stiffness, we find the cell density at which motion arrests varies significantly, but the cell shape remains constant, consistent with the onset of tissue rigidity. In contrast, pharmacological perturbations can significantly alter the cell shape at which tissue dynamics are arrested, consistent with varied amounts of active stress within the tissue. Across all experimental conditions, the final cell shape is well correlated to the cell proliferation rate, and cell cycle inhibition immediately arrests cell motility. Finally, we demonstrate cell cycle variation in junctional tension as a source of active stress within the monolayer. Thus, the architecture and mechanics of epithelial tissue can arise from an interplay between cell mechanics and stresses arising from cell cycle dynamics.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.