Evidence map›Paper›PMID 33649150›Full record

ArticleJournal of bacteriology2021

Evidence for the Mycobacterial Mce4 Transporter Being a Multiprotein Complex.

Laura Rank, Laura E Herring, Miriam Braunstein

Open access · greenAbstract read
In one paragraph

Article in Journal of bacteriology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed
2.1field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 46 citations in OpenAlex.

  1. Article
  2. Mce transport systems inJournal of bacteriology · 2026
    Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. RNA-targeted proteomics identifies YBX1 as critical for efficient HCMV mRNA translation.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  12. Article
  13. Article
  14. Lipid Trafficking in Diverse Bacteria.Accounts of chemical research · 2025
    Review
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Laura RankDepartment of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
Laura E HerringUNC Michael Hooker Proteomics Core Facility, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
Miriam BraunsteinDepartment of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA miriam_braunstein@med.unc.edu.ORCID 0000-0003-1180-0030
University of North Carolina at Chapel Hill · US

Funding

Virology Research Program (Program 4)P30CA016086 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI David Darr · 1985 to 2026
$201.5M
Systematic analysis of components of mycobacterial Mce transportersR21AI135899 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI BRAUNSTEIN, MIRIAM S. · 2018 to 2019
$423k
NCI NIH HHS P30 CA016086NIAID NIH HHS R21 AI135899
6 · The paper itself

Abstract

Mycobacteria possess Mce transporters that import lipids and are thought to function analogously to ATP-binding cassette (ABC) transporters. However, whereas ABC transporters import substrates using a single solute-binding protein (SBP) to deliver a substrate to permease proteins in the membrane, mycobacterial Mce transporters have a potential for six SBPs (MceA to MceF) working with a pair of permeases (YrbEA and YrbEB), a cytoplasmic ATPase (MceG), and multiple Mce-associated membrane (Mam) and orphaned Mam (Omam) proteins to transport lipids. In this study, we used the model mycobacterium

Indexed as

Adenosine TriphosphatasesBacterial ProteinsBiological TransportCholesterolMembrane Transport ProteinsMultiprotein ComplexesMycobacterium smegmatisOperonAdenosine TriphosphatasesBacterial ProteinsCholesterolMembrane Transport ProteinsMultiprotein Complexescell wallcholesterolMceMycobacteriumtransporters

Identifiers

PMID33649150
PMCPMC8088607
OpenAlexW3134192374

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.