ArticleScience immunology2021
Bispecific antibodies targeting mutant
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Article in Science immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 121 papers.
0numbers the graph read from it
0cells of the map it votes in
121citing papers in PubMed
17.8field-weighted citation impact, top 1% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
121 citing papers in PubMed, 163 citations in OpenAlex.
- Second primary cancers following hematologic malignancies: Epidemiology, pathobiology and clinical management.Human vaccines & immunotherapeutics · 2026Review
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- Functional screening of TCR-like antibodies using STAR-T cell library for cancer immunotherapy.EMBO molecular medicine · 2026Article
- Bispecific antibodies and CAR T cells targeting a TP53 mutation-associated neoantigen show discordant affinity requirements.The Journal of clinical investigation · 2026Article
- Protein engineering: status report.Protein engineering, design & selection : PEDS · 2026Review
- Advancing immunotherapy via multiple immune cells co-engagement.Frontiers in immunology · 2026Review
- Avidity-optimized TCR-T cells target KRAS neoantigens for potent cancer clearance and tumor microenvironment remodeling.Frontiers in immunology · 2026Article
- Advances in Neoantigen-Based Cancer Vaccines.Cancers · 2025Review
- Engineered antibodies that stabilize drug-modified KRASNature communications · 2025Article
- Lymphodepleting chemotherapy potentiates neoantigen-directed T cell therapy by enhancing antigen presentation.Cell reports. Medicine · 2025Article
- Article
- Bispecific antibodies and nanotechnology: a strategic alliance in cancer immunotherapy.Molecular cancer · 2025Review
- Oncogenic KRAS mutations drive immune suppression through immune-related regulatory network and metabolic reprogramming.Cell death & disease · 2025Review
- A TCR-mimic bispecific antibody reduces HIV-1 provirus and delays viral rebound in HLA-matched humanized mice.bioRxiv : the preprint server for biology · 2025Article
- Targeting peptide antigens using a multiallelic MHC I-binding system.Nature biotechnology · 2025Article
- Targeting mutated KRAS by HLA-A*02:01 restricted anti-KRAS TCR-mimic CAR and bispecific T cell engager.Journal of molecular medicine (Berlin, Germany) · 2025Article
- Neoantigen-driven personalized tumor therapy: An update from discovery to clinical application.Chinese medical journal · 2025Review
- HERV-derived epitopes represent new targets for T-cell-based immunotherapies in ovarian cancer.Journal for immunotherapy of cancer · 2025Article
- Review
61 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
26 authors at 4 institutions in 1 country.
Jacqueline DouglassLudwig Center, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.ORCID 0000-0002-9113-7090
Emily Han-Chung HsiueLudwig Center, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.ORCID 0000-0001-5882-5142
Brian J MogLudwig Center, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.ORCID 0000-0001-9988-7147
Michael S HwangLudwig Center, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.
Sarah R DiNapoliLudwig Center, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.ORCID 0000-0002-3675-9030
Alexander H PearlmanLudwig Center, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.ORCID 0000-0002-3504-7517
Michelle S MillerHoward Hughes Medical Institute, Chevy Chase, MD 20815, USA.ORCID 0000-0003-1972-4503
Katharine M WrightHoward Hughes Medical Institute, Chevy Chase, MD 20815, USA.ORCID 0000-0001-9060-3849
P Aitana AzurmendiHoward Hughes Medical Institute, Chevy Chase, MD 20815, USA.ORCID 0000-0001-8979-641X
Qing WangLudwig Center, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA. vogelbe@jhmi.edu qing@completeomics.com sbzhou@jhmi.edu.ORCID 0000-0002-7979-766X
Suman PaulLudwig Center, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.ORCID 0000-0001-9357-3702
Annika SchaeferLudwig Center, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.ORCID 0000-0002-0501-2751
Andrew D SkoraLudwig Center, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.ORCID 0000-0002-3054-5584
Marco Dal MolinLudwig Center, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.ORCID 0000-0003-1581-3576
Maximilian F KonigLudwig Center, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.ORCID 0000-0001-5045-5255
Qiang LiuLudwig Center, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.ORCID 0000-0001-8440-304X
Evangeline WatsonLudwig Center, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.
Yana LiDepartment of Biophysics and Biophysical Chemistry, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.ORCID 0000-0002-8479-3292
Michael B MurphyCytiva, Marlborough, MA 01752, USA.ORCID 0000-0002-9806-420X
Drew M PardollBloomberg~Kimmel Institute for Cancer Immunotherapy, Sidney Kimmel Comprehensive Cancer Center, Baltimore, MD 21287, USA.ORCID 0000-0001-6215-1013
Chetan BettegowdaLudwig Center, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.ORCID 0000-0001-9991-7123
Nickolas PapadopoulosLudwig Center, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.ORCID 0000-0001-7135-7451
Sandra B GabelliDepartment of Biophysics and Biophysical Chemistry, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.ORCID 0000-0003-1205-5204
Kenneth W KinzlerLudwig Center, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.ORCID 0000-0001-5591-1176
Bert VogelsteinLudwig Center, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA. vogelbe@jhmi.edu qing@completeomics.com sbzhou@jhmi.edu.ORCID 0000-0003-0766-3854
Shibin ZhouLudwig Center, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA. vogelbe@jhmi.edu qing@completeomics.com sbzhou@jhmi.edu.ORCID 0000-0003-1941-4425
Howard Hughes Medical Institute · USJohns Hopkins University · USCytel (United States) · USUniversity of Maryland, Baltimore · US
Funding
Translational Research Central ServicesP30CA006973 · NCI · JOHNS HOPKINS UNIVERSITY · PI WILLIAM George NELSON · 1985 to 2026
$208.6MMEDICAL SCIENTIST TRAINING PROGRAMT32GM007309 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI COX, ANDREA L · 1985 to 2019
$43.2MMedical Scientist Training ProgramT32GM136577 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI ANDREA L COX · 2020 to 2026
$13.4MONCOLOGY: CHEMOTHERAPY, IMMUNOLOGY, BIOLOGYT32CA009071 · NCI · JOHNS HOPKINS UNIVERSITY · PI Mary Y Armanios, Nilofer S. Azad · 1985 to 2026
$12.8MMulti-analyte Approach for Earlier Detection of Cancers in Non Plasma BiofluidsU01CA230691 · NCI · JOHNS HOPKINS UNIVERSITY · PI Nishant Agrawal, CHETAN BETTEGOWDA · 2018 to 2026
$6.7MMultidisciplinary Rheumatology Training ProgramT32AR048522 · NIAMS · JOHNS HOPKINS UNIVERSITY · PI CLIFTON O BINGHAM, LIVIA A CASCIOLA-ROSEN · 2003 to 2026
$6.4MInterrogating malignant gliomas using released tumor DNA in cerebrospinal fluidR37CA230400 · NCI · JOHNS HOPKINS UNIVERSITY · PI BETTEGOWDA, CHETAN · 2018 to 2024
$2.6M(PQ 6) Exploiting Frequent Alterations in the PRC2 Complex to Distinguish Benign Neurofibromas from Malignant Peripheral Nerve Sheath TumorsR21CA208723 · NCI · JOHNS HOPKINS UNIVERSITY · PI BETTEGOWDA, CHETAN · 2016 to 2017
$391kNCI NIH HHS P30 CA006973NCI NIH HHS R21 CA208723NCI NIH HHS R37 CA230400NCI NIH HHS T32 CA009071NCI NIH HHS U01 CA230691NIAMS NIH HHS T32 AR048522NIGMS NIH HHS T32 GM007309NIGMS NIH HHS T32 GM136577
Abstract
Mutations in the
Indexed as
Antigens, NeoplasmAmino Acid SequenceAnimalsAntibodies, BispecificBiomarkers, TumorCell LineCross ReactionsHLA AntigensHumansLymphocyte ActivationMutant ProteinsMutationPeptide FragmentsProtein Bindingras ProteinsT-Lymphocyte SubsetsAntibodies, BispecificAntigens, NeoplasmBiomarkers, TumorHLA AntigensMutant ProteinsPeptide Fragmentsras Proteins
Identifiers
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.