Evidence map›Paper›PMID 33649050›Full record

ArticleInfection and immunity2021

Broadly Reactive Human Monoclonal Antibodies Targeting the Pneumococcal Histidine Triad Protein Protect against Fatal Pneumococcal Infection.

Jiachen Huang, Aaron D Gingerich, Fredejah Royer, Amy V Paschall, Alma Pena-Briseno, Fikri Y Avci, Jarrod J Mousa

Open access · greenAbstract read
In one paragraph

Article in Infection and immunity, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.7field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 13 citations in OpenAlex.

  1. Review
  2. Human vaccines & immunotherapeutics · 2025
    Review
  3. Clinical microbiology reviews · 2025
    Review
  4. Article
  5. Article
  6. Outsmarting Pathogens with Antibody Engineering.Annual review of chemical and biomolecular engineering · 2023
    Review
  7. Review
  8. Article
  9. Antibodies as drugs-a Keystone Symposia report.Annals of the New York Academy of Sciences · 2023
    Article
  10. Article
  11. Diverse Mechanisms of Protective Anti-Pneumococcal Antibodies.Frontiers in cellular and infection microbiology · 2022
    Review
  12. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Jiachen HuangCenter for Vaccines and Immunology, College of Veterinary Medicine, University of Georgia, Athens, Georgia, USA.
Aaron D GingerichCenter for Vaccines and Immunology, College of Veterinary Medicine, University of Georgia, Athens, Georgia, USA.
Fredejah RoyerCenter for Vaccines and Immunology, College of Veterinary Medicine, University of Georgia, Athens, Georgia, USA.
Amy V PaschallDepartment of Biochemistry and Molecular Biology, University of Georgia, Athens, Georgia, USA.
Alma Pena-BrisenoCenter for Vaccines and Immunology, College of Veterinary Medicine, University of Georgia, Athens, Georgia, USA.
Fikri Y AvciDepartment of Biochemistry and Molecular Biology, University of Georgia, Athens, Georgia, USA.ORCID 0000-0002-1902-7532
Jarrod J MousaCenter for Vaccines and Immunology, College of Veterinary Medicine, University of Georgia, Athens, Georgia, USA jarrod.mousa@uga.edu.ORCID 0000-0003-4709-2478
University of Georgia · US

Funding

Implementing a Maternal health and PRegnancy Outcomes Vision for Everyone (IMPROVE)UL1TR002378 · NCATS · EMORY UNIVERSITY · PI Andres J Garcia, Elizabeth O. Ofili · 2017 to 2026
$92.1M
Molecular Mechanisms for Carbohydrate Presentation to CD4+ T cells by MHCII PathwayR01AI123383 · NIAID · UNIVERSITY OF GEORGIA · PI Fikri Y Avci · 2016 to 2026
$4.2M
PREP at University of GeorgiaR25GM109435 · NIGMS · UNIVERSITY OF GEORGIA · PI DOLAN, ERIN L, KLONOWSKI, KIMBERLY D. · 2014 to 2024
$3.4M
Therapeutic antibodies to treat Pneumocystis pneumonia in a nonhuman primate model of HIV infectionK01OD026569 · OD · UNIVERSITY OF GEORGIA · PI MOUSA, JARROD · 2018 to 2020
$1.0M
NCATS NIH HHS UL1 TR002378NIAID NIH HHS R01 AI123383NIGMS NIH HHS R25 GM109435NIH HHS K01 OD026569
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Antibodies, MonoclonalAntibody SpecificityDose-Response Relationship, ImmunologicEpitopesHost-Pathogen InteractionsHumansHydrolasesPneumococcal InfectionsProtein BindingSerogroupStreptococcus pneumoniaeAntibodies, MonoclonalEpitopeshistidine triad proteinHydrolasesmonoclonal antibodiespneumococcal infectionStreptococcus pneumoniae

Identifiers

PMID33649050
PMCPMC8091081
OpenAlexW3135542108

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.