ArticleBritish journal of anaesthesia2021
Electrophysiological signatures of acute systemic lipopolysaccharide-induced inflammation: potential implications for delirium science.
Article in British journal of anaesthesia, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 24 citations in OpenAlex.
- Inflammation and delirium in critically Ill patients: a review.Frontiers in aging neuroscience · 2026Pooled it
- Peak alpha frequency and spectral exponent in postoperative delirium: a high-density EEG cohort study.BJA open · 2026Article
- Animal models of delirium: a narrative review.Translational psychiatry · 2026Review
- Bedside EEG for rapid diagnosis of delirium.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2026Review
- Age-Dependent Regulation of Hippocampal Inflammation by the Mitochondrial Translocator Protein in Mice.Aging cell · 2025Article
- Mechanisms of perioperative neuronal injury and the search for therapies.British journal of anaesthesia · 2025Article
- Chemokine associations with blood cerebrospinal fluid (CSF) barrier permeability and delirium.Brain, behavior, & immunity - health · 2025Article
- The Pathophysiology and Biomarkers of Delirium.Seminars in neurology · 2024Review
- Discovery of novel protective agents for infection-related delirium through bispectral electroencephalography.Translational psychiatry · 2024Article
- International Delirium Pathophysiology & Electrophysiology Network for Data sharing (iDEPEND).BJA open · 2024Article
- Delirium is associated with loss of feedback cortical connectivity.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
- The U-shaped curve predicting cognitive vulnerability to delirium severity.Brain : a journal of neurology · 2023Article
- Preclinical and translational models for delirium: Recommendations for future research from the NIDUS delirium network.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2023Review
- Inflammation Disrupts the Brain Network of Executive Function after Cardiac Surgery.Annals of surgery · 2023Article
- Delirium and Cortical Complexity: Divergent Changes in Alpha and Theta Bands.The journals of gerontology. Series A, Biological sciences and medical sciences · 2022Article
- Postoperative delirium and changes in the blood-brain barrier, neuroinflammation, and cerebrospinal fluid lactate: a prospective cohort study.British journal of anaesthesia · 2022Article
- Article
- Reduced Electroencephalogram Complexity in Postoperative Delirium.The journals of gerontology. Series A, Biological sciences and medical sciences · 2022Article
- (R)-Ketamine attenuates LPS-induced endotoxin-derived delirium through inhibition of neuroinflammation.Psychopharmacology · 2021Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
Abstract
backgroundNovel preventive therapies are needed for postoperative delirium, which especially affects older patients. A mouse model is presented that captures inflammation-associated cortical slow wave activity (SWA) observed in patients, allowing exploration of the mechanistic role of prostaglandin-adenosine signalling.
methodsEEG and cortical cytokine measurements (interleukin 6, monocyte chemoattractant protein-1) were obtained from adult and aged mice. Behaviour, SWA, and functional connectivity were assayed before and after systemic administration of lipopolysaccharide (LPS)+piroxicam (cyclooxygenase inhibitor) or LPS+caffeine (adenosine receptor antagonist). To avoid the confounder of inflammation-driven changes in movement which alter SWA and connectivity, electrophysiological recordings were classified as occurring during quiescence or movement, and propensity score matching was used to match distributions of movement magnitude between baseline and post-LPS administration.
resultsLPS produces increases in cortical cytokines and behavioural quiescence. In movement-matched data, LPS produces increases in SWA (likelihood-ratio test: χ
conclusionsCytokine-SWA correlations during wakefulness are consistent with observations in patients with delirium. Absence of connectivity effects after accounting for movement changes suggests decreased connectivity in patients is a biomarker of hypoactivity. Exaggerated effects in quiescent aged animals are consistent with increased hypoactive delirium in older patients. Prostaglandin-adenosine signalling may link inflammation to neural changes and hence delirium.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.