ArticleInternational review of neurobiology2021
Neurobiological aspects of pain in the context of alcohol use disorder.
Article in International review of neurobiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 27 citations in OpenAlex.
- Mitochondrial dysfunction at the intersection of alcohol use disorder and chronic pain.Function (Oxford, England) · 2026Review
- A short communication of pain outcomes following a pharmacist-delivered alcohol and opioid use reduction intervention.Drug and alcohol dependence reports · 2026Article
- Persistent inflammation does not promote aversion-resistant binge-like alcohol drinking in rats.Alcohol (Fayetteville, N.Y.) · 2025Article
- Intersection of alcohol use, pain symptoms, and negative affect in total knee arthroplasty patients and people with HIV.The journal of pain · 2025Article
- Alcohol and cannabis use for pain management: Translational findings of relative risks, benefits, and interactions.Physiology & behavior · 2025Review
- Neural, Motivational, and Psychological Measures of Pain Avoidance Predict Future Alcohol Use in Adult Drinkers.Addiction biology · 2025Article
- Within and Beyond the Binary: Sex and Gender Differences in Pain and Alcohol Use Disorder.Current addiction reports · 2024Article
- Electroencephalography-Based Effects of Acute Alcohol Intake on the Pain Matrix.Brain sciences · 2023Article
- Sex-specific biobehavioral regulation of persistent inflammatory pain by alcohol.Alcohol, clinical & experimental research · 2023Article
- Agmatine reduces alcohol drinking and produces antinociceptive effects in rodent models of alcohol use disorder.Alcohol (Fayetteville, N.Y.) · 2023Article
- Effects of ethanol on mechanical allodynia and dynamic weight bearing in male and female mice with spared nerve injury.Alcohol, clinical & experimental research · 2023Article
- The hidden risks of alcohol use for pain relief.Alcohol, clinical & experimental research · 2023Article
- Influence of early-life adversity on responses to acute and chronic ethanol in female mice.Alcohol, clinical & experimental research · 2023Article
- Chronic pain, chronic stress and substance use: overlapping mechanisms and implications.Frontiers in pain research (Lausanne, Switzerland) · 2023Review
- Alcohol amplifies cingulate cortex signaling and facilitates immobilization-induced hyperalgesia in female rats.Neuroscience letters · 2021Article
- Pathophysiological Consequences of At-Risk Alcohol Use; Implications for Comorbidity Risk in Persons Living With Human Immunodeficiency Virus.Frontiers in physiology · 2021Review
- The Convergent Neuroscience of Affective Pain and Substance Use Disorder.Alcohol research : current reviews · 2021Review
- Chronic inflammatory pain alters alcohol-regulated frontocortical signaling and associations between alcohol drinking and thermal sensitivity.Neurobiology of pain (Cambridge, Mass.)Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Alcohol is an effective and widely utilized analgesic. However, the chronic use of alcohol can actually facilitate nociceptive sensitivity over time, a condition known as hyperalgesia. Excessive and uncontrollable alcohol drinking is also a hallmark feature of alcohol use disorder (AUD). Both AUD and chronic pain are typically accompanied by negative affective states that may underlie reinforcement mechanisms contributing to AUD maintenance or progression. Frequent utilization of alcohol to relieve pain in individuals suffering from AUD or other chronic pain conditions may thus represent a powerful negative reinforcement construct. This chapter will describe ties between alcohol-mediated pain relief and potential exacerbation of AUD. We describe neurobiological systems engaged in alcohol analgesia as well as systems recruited in the development and maintenance of AUD and hyperalgesia. Although few effective therapies exist for either chronic pain or AUD, the common interaction of these conditions will likely lead the way for promising new discoveries of more effective and even simultaneous treatment of AUD and co-morbid hyperalgesia. An abundance of neurobiological findings from multiple laboratories has implicated a potentiation of central amygdala (CeA) signaling in both pain and AUD, and these data also suggest that attenuation of stress-related systems (including corticotropin-releasing factor, vasopressin, and glucocorticoid receptor activity) would be particularly effective and comprehensive therapeutic strategies targeting the critical intersection of somatic and motivational mechanisms driving AUD, including alcohol-induced hyperalgesia.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.