ArticleeLife2021
New light shed on the early evolution of limb-bone growth plate and bone marrow.
Article in eLife, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
9 citing papers in PubMed, 14 citations in OpenAlex.
- Diverse ossification pathways in the lower jaw of Sclerocephalus (Lower Permian) as revealed by the first record of chondroid bone in Amphibia.Scientific reports · 2026Article
- Physical and chemical niche of human growth plate for polarized bone development.Nature communications · 2025Article
- Widespread presence of bone marrow-like hematopoietic stem cell niche in invertebrate skeletons.Science advances · 2025Article
- The cellular basis of cartilage growth and shape change in larval and metamorphosing Xenopus frogs.PloS one · 2023Article
- Endogenous Retroviruses Augment Amphibian (Xenopus laevis) Tadpole Antiviral Protection.Journal of virology · 2022Article
- Osteohistology of Greererpeton provides insight into the life history of an early Carboniferous tetrapod.Journal of anatomy · 2021Review
- Unraveling the history of limb bones.eLife · 2021Article
- Mineralized Cartilage and Bone-Like Tissues in Chondrichthyans Offer Potential Insights Into the Evolution and Development of Mineralized Tissues in the Vertebrate Endoskeleton.Frontiers in genetics · 2021Review
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Authors and funding
7 authors at 4 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The production of blood cells (haematopoiesis) occurs in the limb bones of most tetrapods but is absent in the fin bones of ray-finned fish. When did long bones start producing blood cells? Recent hypotheses suggested that haematopoiesis migrated into long bones prior to the water-to-land transition and protected newly-produced blood cells from harsher environmental conditions. However, little fossil evidence to support these hypotheses has been provided so far. Observations of the humeral microarchitecture of stem-tetrapods, batrachians, and amniotes were performed using classical sectioning and three-dimensional synchrotron virtual histology. They show that Permian tetrapods seem to be among the first to exhibit a centralised marrow organisation, which allows haematopoiesis as in extant amniotes. Not only does our study demonstrate that long-bone haematopoiesis was probably not an exaptation to the water-to-land transition but it sheds light on the early evolution of limb-bone development and the sequence of bone-marrow functional acquisitions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.