Evidence map›Paper›PMID 33648558›Full record

ArticleTrials2021

Effect of patient-controlled intravenous analgesia combined with flurbiprofen axetil and dezocine on postoperative analgesia for lobectomy (EPIC-FAD): a trial protocol.

Jian Zhou, Qiang Pu, Lin Lin, Weelic Chong, Boran Chen, Yang Hai, Fei Liu, Lunxu Liu

Open access · goldAbstract readClinical Trial Protocol
PubMed Full text at PMC Publisher
In one paragraph

Article in Trials, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 97% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 0 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Jian ZhouDepartment of Thoracic Surgery, West China Hospital, Sichuan University, Chengdu, No. 37, Guoxue Alley, Chengdu, 610041, Sichuan, China.
Qiang PuDepartment of Thoracic Surgery, West China Hospital, Sichuan University, Chengdu, No. 37, Guoxue Alley, Chengdu, 610041, Sichuan, China.
Lin LinDepartment of Thoracic Surgery, West China Hospital, Sichuan University, Chengdu, No. 37, Guoxue Alley, Chengdu, 610041, Sichuan, China.
Weelic ChongSidney Kimmel School of Medicine, Thomas Jefferson University, Philadelphia, PA, USA.
Boran ChenWest China School of Medicine, Sichuan University, Chengdu, China.
Yang HaiDepartment of Thoracic Surgery, West China Hospital, Sichuan University, Chengdu, No. 37, Guoxue Alley, Chengdu, 610041, Sichuan, China.
Fei LiuDepartment of Anesthesiology, West China Hospital, Sichuan University, Chengdu, China.
Lunxu LiuDepartment of Thoracic Surgery, West China Hospital, Sichuan University, Chengdu, No. 37, Guoxue Alley, Chengdu, 610041, Sichuan, China. lunxu_liu@aliyun.com.
Sichuan University · CNThomas Jefferson University · USWest China Hospital of Sichuan University · CN

Funding

Key Science and Technology Program of Sichuan Province, China 2016FZ0118West China Hospital, Sichuan University 2019HXFH060West China Hospital, Sichuan University ZYGD18021, ZYJC18009
6 · The paper itself

Abstract

backgroundThe optimal analgesic strategy for surgical pain after lobectomy remains undefined. To compare the combination of flurbiprofen axetil and dezocine with flurbiprofen axetil alone and dezocine alone, in post-lobectomy patients.

methodsA single-center, parallel-design double-blind superiority trial, with 5 groups (1:1:1:1:1 ratio) with different combinations of flurbiprofen and dezocine. Patients scheduled for lobectomy will be recruited. The primary outcome is total sufentanil use in patient-controlled intravenous analgesia within the first 24 postoperative hours. Secondary outcomes include pain numeric rating scales at 6th, 12th, 24th, 48th, and 72th postoperative hours, and on the 1st, 3rd, and 6th postoperative months at rest and during coughing, adverse effects from experimental drug treatment, sufentanil use at other time points, analgesia cost, time to chest tube removal, length of hospital stay, time to pass first flatus, and serum level of cytokines. Doctors, patients, and nurses are blinded, and only the manager is unblinded. Analysis is intention-to-treat. Statistical analysis is pre-specified. Statistical comparison of the treatment groups includes one-way analysis of variance followed by Tukey's post hoc test. DISCUSSION: Trial did not begin to recruit. Participant recruitment start date is planned to be June 1, 2020. Approximate recruitment end date is May 31, 2021. If successful, the trial may shed light on the use of certain analgesic combinations in post-lobectomy pain control.

trial registrationChinese Clinical Trial Registry ChiCTR1800018563 . Registered on September 25, 2018.

Indexed as

FlurbiprofenAnalgesia, Patient-ControlledAnalgesics, OpioidBridged Bicyclo Compounds, HeterocyclicDouble-Blind MethodEquivalence Trials as TopicFlavin-Adenine DinucleotideHumansPostoperative PainRandomized Controlled Trials as TopicTetrahydronaphthalenesAnalgesics, OpioidBridged Bicyclo Compounds, HeterocyclicdezocineFlavin-Adenine DinucleotideFlurbiprofenflurbiprofen axetilTetrahydronaphthalenesDezocineLobectomyPatient-controlled intravenous analgesia flurbiprofen axetilPostoperative analgesia

Identifiers

PMID33648558
PMCPMC7923454
OpenAlexW3134096434

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.