Evidence map›Paper›PMID 33648518›Full record

ArticleCardiovascular diabetology2021

Risk for recurrent cardiovascular disease events among patients with diabetes and chronic kidney disease.

Demetria Hubbard, Lisandro D Colantonio, Robert S Rosenson, Todd M Brown, Elizabeth A Jackson, Lei Huang, Kate K Orroth, Stephanie Reading, Mark Woodward, Vera Bittner and 4 more

Open access · goldAbstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Cardiovascular diabetology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
2.2field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 16 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 6 institutions in 4 countries.

Demetria HubbardDepartment of Epidemiology, University of Alabama At Birmingham, 1665 University Blvd, RPHB 140J, Birmingham, AL, 35233-0013, USA.
Lisandro D ColantonioDepartment of Epidemiology, University of Alabama At Birmingham, 1665 University Blvd, RPHB 140J, Birmingham, AL, 35233-0013, USA.
Robert S RosensonMount Sinai Heart, Icahn School of Medicine At Mount Sinai, New York, NY, USA.
Todd M BrownDepartment of Medicine, Division of Cardiovascular Disease, University of Alabama At Birmingham, Birmingham, AL, USA.
Elizabeth A JacksonDepartment of Medicine, Division of Cardiovascular Disease, University of Alabama At Birmingham, Birmingham, AL, USA.
Lei HuangDepartment of Epidemiology, University of Alabama At Birmingham, 1665 University Blvd, RPHB 140J, Birmingham, AL, 35233-0013, USA.
Kate K OrrothCenter for Observational Research, Amgen Inc., Thousand Oaks, CA, USA.
Stephanie ReadingCenter for Observational Research, Amgen Inc., Thousand Oaks, CA, USA.
Mark WoodwardThe George Institute for Global Health, Imperial College, London, UK.
Vera BittnerDepartment of Medicine, Division of Cardiovascular Disease, University of Alabama At Birmingham, Birmingham, AL, USA.
Orlando M GutierrezDepartment of Epidemiology, University of Alabama At Birmingham, 1665 University Blvd, RPHB 140J, Birmingham, AL, 35233-0013, USA.
Monika M SaffordWeill Cornell Medical College, Cornell University, Ithaca, NY, USA.
Michael E FarkouhPeter Munk Cardiac Centre, University of Toronto and Heart and Stroke Richard Lewar Centre of Excellence, Toronto, ON, Canada.
Paul MuntnerDepartment of Epidemiology, University of Alabama At Birmingham, 1665 University Blvd, RPHB 140J, Birmingham, AL, 35233-0013, USA. pmuntner@uab.edu.
University of Alabama at Birmingham · USAmgen (United States) · USCornell University · USIcahn School of Medicine at Mount Sinai · USThe George Institute for Global Health · AUUniversity of Toronto · CA

Funding

University of Alabama at Birmingham's Diabetes Research CenterP30DK079626 · NIDDK · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Kirk Michael Habegger · 2013 to 2026
$19.5M
New York Regional Center for Diabetes Translation Research - Translational Intervention Methodology CoreP30DK111022 · NIDDK · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI JEFFREY GONZALEZ · 2016 to 2026
$7.8M
NIDDK NIH HHS P30 DK079626NIDDK NIH HHS P30 DK111022
6 · The paper itself

Abstract

backgroundAdults who have experienced multiple cardiovascular disease (CVD) events have a very high risk for additional events. Diabetes and chronic kidney disease (CKD) are each associated with an increased risk for recurrent CVD events following a myocardial infarction (MI).

methodsWe compared the risk for recurrent CVD events among US adults with health insurance who were hospitalized for an MI between 2014 and 2017 and had (1) CVD prior to their MI but were free from diabetes or CKD (prior CVD), and those without CVD prior to their MI who had (2) diabetes only, (3) CKD only and (4) both diabetes and CKD. We followed patients from hospital discharge through December 31, 2018 for recurrent CVD events including coronary, stroke, and peripheral artery events.

resultsAmong 162,730 patients, 55.2% had prior CVD, and 28.3%, 8.3%, and 8.2% had diabetes only, CKD only, and both diabetes and CKD, respectively. The rate for recurrent CVD events per 1000 person-years was 135 among patients with prior CVD and 110, 124 and 171 among those with diabetes only, CKD only and both diabetes and CKD, respectively. Compared to patients with prior CVD, the multivariable-adjusted hazard ratio for recurrent CVD events was 0.92 (95%CI 0.90-0.95), 0.89 (95%CI: 0.85-0.93), and 1.18 (95%CI: 1.14-1.22) among those with diabetes only, CKD only, and both diabetes and CKD, respectively.

conclusionFollowing MI, adults with both diabetes and CKD had a higher risk for recurrent CVD events compared to those with prior CVD without diabetes or CKD.

Indexed as

AgedAged, 80 and overCardiovascular DiseasesDatabases, FactualDiabetes MellitusFemaleHospitalizationHumansHypoglycemic AgentsInsulinMaleMedicareMyocardial InfarctionPeripheral Arterial DiseasePrognosisRecurrenceHypoglycemic AgentsInsulinCardiovascular diseaseChronic kidney diseaseDiabetesEpidemiologyMyocardial infarctionRisk factors

Identifiers

PMID33648518
PMCPMC7923492
OpenAlexW3135591282

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.