SynthesisReproductive biology and endocrinology : RB&E2021
Effect of the time interval between oocyte retrieval and ICSI on embryo development and reproductive outcomes: a systematic review.
Synthesis in Reproductive biology and endocrinology : RB&E, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
11 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Time interval between hCG administration and oocyte retrieval and ART outcomes: an updated systematic review and meta-analysis.Reproductive biology and endocrinology : RB&E · 2023Pooled it
- Immediate post-denudation intracytoplasmic sperm injection is associated with higher fertilization and early cleavage-stage embryo yield: a prospective sibling-oocyte cohort from Libyan ICSI cycles.The Libyan journal of medicine · 2026Article
- Nonlinear effects of post-denudation timing on day 3 embryo outcomes in ICSI and evidence for a translatable optimization window.Journal of translational medicine · 2026Article
- Cumulus cell DNA fragmentation in relation to oocyte yield and blastocyst quality.Reproduction & fertility · 2026Article
- Examining the impact of denudation and ICSI timing on embryological and clinical outcomes in oocyte donation cycles.Journal of assisted reproduction and genetics · 2026Article
- Morphokinetic parameter S2 predicts early embryo developmental potential and associated metabolic pathways.Journal of assisted reproduction and genetics · 2026Article
- The clinical value of short-term insemination: a retrospective analysis of 3496 patients.BMC pregnancy and childbirth · 2025Article
- Optimal ICSI timing on immature oocytes for low prognosis patients under the POSEIDON classification.BMC pregnancy and childbirth · 2024Article
- Personalization of IVF-ICSI workflow based on patient characteristics improves IVF laboratory outcomes and embryo ploidy by PGT-A.Journal of ovarian research · 2022Article
- RescueFrontiers in endocrinology · 2022Article
- Two-six Hours is the Optimal Timing of Intracytoplasmic Sperm Injection After Oocyte Pickup: Single-centre 10 Years Cohort Study.Journal of human reproductive sciencesArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
backgroundIntra-cytoplasmic sperm injection (ICSI) is used in assisted reproductive technology (ART) laboratories. However, there is no consensus regarding the precise time intervals within ICSI cycles [oocyte pick up (OPU), oocyte denudation (DN), and ICSI], and results are inconsistent and contradictory. Thus, we aim to evaluate whether there is a concordance regarding the time intervals used in different laboratories and a concrete time that gives better laboratory and reproductive results.
methodsA systematic review of the literature until July 25, 2020, was performed with the keywords "Oocyte Denudation/Denudation/Oocyte," "Intra-cytoplasmic Sperm Injection/ICSI," "Oocyte/Oocyte maturation/ cumulus," and "Cumulus removal/ removal." Articles and abstracts in English and involving human subjects referring to the effects of oocyte DN time on embryo development and clinical outcomes were included.
resultsOf the 294 evaluated articles, 24 (including 20 full articles and 4 abstracts) were included in this review. Eighteen studies analysed the effect of OPU-DN time on embryo development and clinical outcomes. Most of these studies concluded that OPU-DN time did not influence ICSI outcomes, but some suggested that oocytes should be incubated for a short time before DN to improve oocyte maturity and enhance ICSI outcomes. In addition to reports on positive or negligible effects, adverse effects were reported in 12 studies on DN-ICSI timing. Neither OPU-DN nor DN-ICSI time could improve live birth rate.
conclusionsOocytes should be pre-incubated for a short duration (preferably < 4 h) before DN according to the ART laboratory schedule. More randomised controlled trials are warranted to clarify the effect of DN-ICSI timing on ICSI outcomes.
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