ArticleBMC pulmonary medicine2021
Long-term prognostic factors of clinical success after interventional bronchoscopy in patients with scarring central airway stenosis.
Article in BMC pulmonary medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 23 citations in OpenAlex.
- Management of benign tracheal stenosis: rigid bronchoscopy versus serial cannulas-a retrospective cohort study from a tertiary center.Journal of thoracic disease · 2026Article
- Applying the CHEST Guidelines for Management of Central Airway Obstruction.CHEST pulmonary · 2026Article
- C-Reactive Protein Serum Values in Idiopathic and Autoimmune Subglottic Stenosis.The Laryngoscope · 2026Article
- "We were already there where the narrow path …" Benign tracheal stenosis treatment: narrative review on the state of the art and future direction.Updates in surgery · 2026Review
- Comparison of the difference between post-intubation tracheal stenosis and post-tracheostomy tracheal stenosis: a cross-sectional study.Journal of thoracic disease · 2025Article
- Macrophage STING signaling promotes fibrosis in benign airway stenosis via an IL6-STAT3 pathway.Nature communications · 2025Article
- [Bronchoscopic Interventional Treatment of Mixed Squamous Cell and Glandular Papilloma of Diffuse Trachea: A Case Report and Literature Review].Zhongguo fei ai za zhi = Chinese journal of lung cancer · 2024Review
- Type and morphology affect the success rate of bronchoscopy for postintubation tracheal stenosis.Laryngoscope investigative otolaryngology · 2024Article
- Airway collapse hinders recovery in bronchoscopy therapy for postintubation tracheal stenosis patients.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2024Article
- Biodegradable tracheal stents: our ten-year experience with adult patients.BMC pulmonary medicine · 2024Article
- Incidence of Tracheal Stenosis in ICU Hospitalized COVID-19 Patients: Results from a Prospective, Observational, Multicenter Study.Journal of personalized medicine · 2023Article
- Balloon Bronchoplasty for the Treatment of Bronchial Stenosis After Lung Transplantation: A Single-Center 10-Year Experience.Korean journal of radiology · 2023Article
- Analysis of clinical characteristics of 617 patients with benign airway stenosis.Frontiers in medicine · 2023Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundScarring central airway stenosis (SCAS) is a potentially life-threatening condition with debilitating symptoms. Interventional bronchoscopy is increasingly used to relieve symptoms in patients with SCAS, but recurrent stenosis is frequently observed. Little data exist on the long-term prognosis of interventional bronchoscopy for SCAS. We aimed to assess the prognostic factors of bronchoscopic interventions in patients with SCAS to optimize treatment.
methodsThis was a retrospective study that enrolled 119 consecutive patients with SCAS from January 2010 to April 2019 at our institution. Long-term clinical success was defined as airway stenosis < 50%, no limitation of physical activity, and a stable condition for > 12 months after the last interventional procedure. We compared patients' demographics, airway stenosis characteristics, and interventional procedures between the successful and unsuccessful groups, and identified significant predictors of long-term outcome with univariate and multivariate logistic regression.
resultsA total of 119 patients with 577 therapeutic bronchoscopies were included. Seventy-five (63%) patients were considered to have long-term clinical success. Older age, male gender, smoking, elevated C-reactive protein level, subglottic stenosis, stent or T-tube implantation, previous interventional treatment, and multiple procedures per year were potentially associated with unsuccessful long-term outcomes in the univariate analysis. Current smoker status (odds ratio [OR] 5.70, 95% confidence interval [CI] 1.35-24.17, P = 0.018), subglottic stenosis (OR 4.35, 95% CI 1.31-14.46, P = 0.017), and stent implantation (OR 4.96, 95% CI 1.33-18.48, P = 0.017) were associated with decreased odds of long-term success in the multivariate logistic regression analysis. Of note, there was no significant difference in odds of success between former smokers and nonsmokers.
conclusionsCurrent smoker status, subglottic stenosis, and stent implantation are independent factors associated with reduced long-term efficacy of interventional bronchoscopy for SCAS. Smoking cessation should be encouraged to improve the outcome of therapeutic bronchoscopy.
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