ArticlePoultry science2021
Effects of Taraxacum and Astragalus extracts combined with probiotic Bacillus subtilis and Lactobacillus on Escherichia coli-infected broiler chickens.
Article in Poultry science, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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Who cites it
36 citing papers in PubMed, 76 citations in OpenAlex.
- Synergistic Effects of Plant Polysaccharides and Probiotics: A Novel Dietary Approach for Parkinson's Disease Intervention.Pharmaceuticals (Basel, Switzerland) · 2026Review
- Early antioxidant capacity, intestinal barrier integrity and gut microbiota drive DHAV-3 resistance in ducks.Journal of animal science and biotechnology · 2026Article
- Effects of Mealworm-Based Synbiotics on Productive Performance, Egg Quality, Blood Metabolites, and Gut Health in Laying Japanese Quails.Food science & nutrition · 2025Article
- Functional Effects of Probiotic Lactiplantibacillus plantarum in Alleviation Multidrug-Resistant Escherichia coli-Associated Colitis in BALB/c Mice Model.Probiotics and antimicrobial proteins · 2025Article
- Major Foodborne Bacterial Pathogens in Poultry: Implications for Human Health and the Poultry Industry and Probiotic Mitigation Strategies.Microorganisms · 2025Review
- In vitro probiotic characteristics and whole-genome sequence analysis of lactic acid bacteria isolated from monkey faeces.3 Biotech · 2025Article
- Chinese Herbal Medicine Compound Microecological Agent (C-MEA) Improves Egg Production Performance in Caged Laying Ducks via Microbiota-Gut-Ovary Axis.Veterinary sciences · 2025Article
- Adding dandelion to rabbit diets: enhancing the growth performance and meat quality by altering immune competence and gut microbiota.Microbiology spectrum · 2025Article
- Preliminary Purification and Partial Characterization of a Functional Bacteriocin of Lacticaseibacillus paracasei Zhang and Mining for its Gene Cluster.Probiotics and antimicrobial proteins · 2025Article
- Oral supplementation withFrontiers in veterinary science · 2025Article
- Effects of a powder made from three medicinal plants on growth performance, intestinal health, antioxidant activity, and anti-inflammatory ability in Xianghuang chickens.Frontiers in veterinary science · 2025Article
- Impact of Chlorella vulgaris and probiotic supplementation on performance, immunity and intestinal microbiota of broiler chickens.PloS one · 2025Article
- Lonicera japonica protects Pelodiscus sinensis by inhibiting the biofilm formation of Aeromonas hydrophila.Applied microbiology and biotechnology · 2024Article
- Abh, AbrB3, and Spo0A play distinct regulatory roles during polymyxin synthesis inMicrobiology spectrum · 2024Article
- Palygorskite improves growth performance and prevents liver damage in avian pathogenic Escherichia coli-challenged broiler chickens at an early age.Journal of animal science · 2024Article
- Effects of different addition levels of CHM-JM113 on growth performance, antioxidant capacity, organ index, and intestinal health of AA broilers.Frontiers in veterinary science · 2024Article
- Diet Supplementation with Prinsepiae Nux Extract in Broiler Chickens: Its Effect on Growth Performance and Expression of Antioxidant, Pro-Inflammatory, and Heat Shock Protein Genes.Animals : an open access journal from MDPI · 2023Article
- Antimicrobial Activity and Mechanisms of Walnut Green Husk Extract.Molecules (Basel, Switzerland) · 2023Article
- Antimicrobial activity of phenyllactic acid against Klebsiella pneumoniae and its effect on cell wall membrane and genomic DNA.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2023Article
- Gut Microbial Diversity Analysis of Different Native Chickens and Screening of Chicken-Derived Probiotics.Animals : an open access journal from MDPI · 2023Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Diarrhea caused by Escherichia coli (E. coli) is one of the most common diseases that affects the growth and development of poultry. This study was conducted to investigate the synergistic effects of traditional Chinese medicine (TCM) combined with probiotics against E. coli infection and its mechanism in broiler chickens. The optimal proportion formula TCM and probiotics was screened by orthogonal test and range analysis method; the in vitro antibacterial activity was based on the Oxford cup method. Isolated pathogenic E. coli was injected subcutaneously into the neck of the broilers to establish an E. coli-infected model. The broilers were administrated with drugs in drinking water daily for 7 d before and after E. coli infection. The diarrhea rate, mortality, body weight (BW) gain, feed intake, immune organ index, intestinal and hepatic histopathological changes were monitored. The expression of IL-2, IL-10, and TLR-4 mRNA in the intestinal tissues was measured by RT-PCR. Our results showed that the optimal proportion formula of Taraxacum extracts: total flavonoids of Astragalus: polysaccharides of Astragalus: probiotics was 5: 2: 2: 2; TCM combined with probiotics was highly sensitive to E. coli. TCM combined with probiotics synergistically increased BW gain, decreased the diarrhea rate and mortality of broilers, alleviated intestinal and hepatic pathological changes, accompanied by the increase of IL-2 and IL-10 mRNA expression and the inhibition of TLR-4 mRNA expression. It suggests that the combination of TCM and probiotics may produce a synergistic protective effect against E. coli infection by improving the indicators of diarrhea and regulating the expression of IL-2, IL-10, and TLR-4 mRNA in broiler chickens. The synergistic interactions between TCM and probiotics represent a promising strategy for the treatment of E. coli infection.
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