Evidence map›Paper›PMID 33647675›Full record

ArticleInternational journal for parasitology. Drugs and drug resistance2021

Anti-protozoal activity of Thymol and a Thymol ester against Cryptosporidium parvum in cell culture.

Astrid Dominguez-Uscanga, Danielle Francesca Aycart, Kun Li, William H Witola, Juan E Andrade Laborde

Open access · goldAbstract read
In one paragraph

Article in International journal for parasitology. Drugs and drug resistance, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
2.3field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 17 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. Microorganisms · 2023
    Article
  8. Article
  9. In vitro efficacy of plumbagin and thymol againstJournal of parasitic diseases : official organ of the Indian Society for Parasitology · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

Astrid Dominguez-UscangaDepartment of Food Science and Human Nutrition, University of Illinois at Urbana-Champaign, Urbana, IL, 61801, USA.
Danielle Francesca AycartDepartment of Food Science and Human Nutrition, University of Illinois at Urbana-Champaign, Urbana, IL, 61801, USA; Facultad de Ciencias de la Vida, Escuela Superior Politécnica del Litoral, Guayaquil, Ecuador.
Kun LiDepartment of Pathobiology, College of Veterinary Medicine, University of Illinois at Urbana-Champaign, 61801, USA.
William H WitolaDepartment of Pathobiology, College of Veterinary Medicine, University of Illinois at Urbana-Champaign, 61801, USA.
Juan E Andrade LabordeFood Science and Human Nutrition Department, University of Florida, Gainesville, FL, 32611, USA. Electronic address: jandrade2@ufl.edu.
University of Illinois Urbana-Champaign · USUniversity of Florida · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cryptosporidium parvum is a protozoan parasite that infects intestinal epithelial cells causing malabsorption and severe diarrhea. The monoterpene thymol has been reported to have antifungal and antibacterial properties but less is known about the antiparasitic effect of this compound. Terpenes are sometimes unsuitable for therapeutic and food applications because of their instability. Esterification of terpenes eliminates this disadvantage. The present study evaluates the effects of thymol (Th) and a thymol ester, thymol octanoate (TO), against C. parvum infectivity in vitro. The cytotoxicity IC

Indexed as

CryptosporidiosisCryptosporidiumCryptosporidium parvumAnimalsCell Culture TechniquesEstersHumansThymolEstersThymolAntiparasiticCryptosporidium parvumEsterificationThymolThymol octanoate

Identifiers

PMID33647675
PMCPMC7932911
OpenAlexW3129978141

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.