Evidence map›Paper›PMID 33647528›Full record

ReviewCurrent opinion in microbiology2021

PAS domains in bacterial signal transduction.

Erwin C Stuffle, Mark S Johnson, Kylie J Watts

Open access · greenAbstract readReview
In one paragraph

Review in Current opinion in microbiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed
8.2field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed, 72 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Structural Basis of a Novel Heme Binding Bacterial One-Component Switch.bioRxiv : the preprint server for biology · 2026
    Article
  5. Review
  6. Type IV pilin regulation: a transcriptional overview.Critical reviews in microbiology · 2026
    Review
  7. Article
  8. Review
  9. Review
  10. Review
  11. Journal of fungi (Basel, Switzerland) · 2025
    Article
  12. Article
  13. Review
  14. Article
  15. Review
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Erwin C StuffleDivision of Microbiology and Molecular Genetics, Alumni Hall for Basic Sciences, Loma Linda University, Loma Linda, CA, 92350, USA.
Mark S JohnsonDivision of Microbiology and Molecular Genetics, Alumni Hall for Basic Sciences, Loma Linda University, Loma Linda, CA, 92350, USA.
Kylie J WattsDivision of Microbiology and Molecular Genetics, Alumni Hall for Basic Sciences, Loma Linda University, Loma Linda, CA, 92350, USA. Electronic address: kwatts@llu.edu.
Loma Linda University · US

Funding

Sensing, Signaling and the Role of Aer-2-Regulated Chemosensory SystemsR01GM108655 · NIGMS · LOMA LINDA UNIVERSITY · PI WATTS, KYLIE JANE · 2016 to 2020
$1.5M
NIGMS NIH HHS R01 GM108655
6 · The paper itself

Abstract

PAS domains are widespread, versatile domains found in proteins from all kingdoms of life. The PAS fold is composed of an antiparallel β-sheet with several flanking α-helices, and contains a conserved cleft for cofactor or ligand binding. The last few years have seen a prodigious increase in identified PAS domains and resolved PAS structures, including structures with effector and other domains. New bacterial PAS ligands have been discovered, and structure-function studies have improved our understanding of PAS signaling mechanisms. The list of bacterial PAS functions has now expanded to include roles in signal sensing, modulation, transduction, dimerization, protein interaction, and cellular localization.

Indexed as

Bacterial ProteinsSignal TransductionBacteriaProtein Structure, SecondaryProtein Structure, TertiaryBacterial Proteins

Identifiers

PMID33647528
PMCPMC8169565
OpenAlexW3134212693

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.