Evidence map›Paper›PMID 33647370›Full record

ArticleInternational journal of radiation oncology, biology, physics2021

Caloric Restriction Impairs Regulatory T cells Within the Tumor Microenvironment After Radiation and Primes Effector T cells.

Gregor Manukian, Charles Kivolowitz, Tiziana DeAngelis, Anuradha A Shastri, Jason E Savage, Kevin Camphausen, Ulrich Rodeck, Jelani C Zarif, Nicole L Simone

Open access · greenAbstract read
In one paragraph

Article in International journal of radiation oncology, biology, physics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
2.0field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 36 citations in OpenAlex.

  1. Review
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  7. Article
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  9. Article
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  11. Nutritional modulation of antitumor immunity.Current opinion in immunology · 2024
    Review
  12. Review
  13. Nutrients: Signal 4 in T cell immunity.The Journal of experimental medicine · 2024
    Article
  14. Article
  15. Review
  16. Dietary fat and lipid metabolism in the tumor microenvironment.Biochimica et biophysica acta. Reviews on cancer · 2023
    Review
  17. Review
  18. Low-Dose Non-Targeted Effects and Mitochondrial Control.International journal of molecular sciences · 2023
    Review
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Gregor ManukianDepartment of Radiation Oncology, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, Pennsylvania.
Charles KivolowitzDepartment of Radiation Oncology, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, Pennsylvania.
Tiziana DeAngelisDepartment of Radiation Oncology, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, Pennsylvania.
Anuradha A ShastriDepartment of Radiation Oncology, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, Pennsylvania.
Jason E SavageRadiation Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland.
Kevin CamphausenRadiation Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland.
Ulrich RodeckDepartment of Dermatology and Cutaneous Biology, Thomas Jefferson University, Philadelphia, Pennsylvania.
Jelani C ZarifDepartment of Oncology, Prostate Cancer Program, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins School of Medicine, Baltimore, Maryland.
Nicole L SimoneDepartment of Radiation Oncology, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, Pennsylvania. Electronic address: nicole.simone@jefferson.edu.
Thomas Jefferson University · USNational Cancer Institute · USSidney Kimmel Comprehensive Cancer Center · US

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI SELWYN M VICKERS · 1985 to 2026
$347.4M
X-Ray Crystallography and Macromolecular CharacterizationP30CA056036 · NCI · THOMAS JEFFERSON UNIVERSITY · PI Claudio Guillermo Giraudo · 1995 to 2026
$94.8M
Pre-clinical Development of Radiation Sensitizers for Patients with GlioblastomaZIASC010372 · NCI · DIVISION OF CLINICAL SCIENCES - NCI · PI CAMPHAUSEN, KEVIN · 2009 to 2025
$12.0M
Diet Modification to Augment Radiation for Breast Cancer Brain MetastasesR01CA227479 · NCI · THOMAS JEFFERSON UNIVERSITY · PI SIMONE, NICOLE L · 2018 to 2022
$2.0M
Targeting M2-Tumor Associated Macrophages to overcome tumor immunity in metastatic castration-resistant prostate cancerK22CA237623 · NCI · JOHNS HOPKINS UNIVERSITY · PI ZARIF, JELANI CHINELO · 2019 to 2021
$461k
NCI NIH HHS K22 CA237623NCI NIH HHS P30 CA008748NCI NIH HHS P30 CA056036NCI NIH HHS R01 CA227479
6 · The paper itself

Abstract

Outcomes for triple negative breast cancer (TNBC) are poor and may be improved by increasing CD8

Indexed as

Caloric RestrictionAdultAgedAnimalsCD4-Positive T-LymphocytesCD8-Positive T-LymphocytesCombined Modality TherapyDisease ProgressionFemaleFlow CytometryForkhead Transcription FactorsHumansInterleukin-10 Receptor beta SubunitInterleukin-2 Receptor alpha SubunitInterleukin Receptor Common gamma SubunitLymphocyte DepletionForkhead Transcription FactorsFOXP3 protein, humanIL2RA protein, humanIL2RG protein, humanInterleukin-10 Receptor beta SubunitInterleukin-2 Receptor alpha SubunitInterleukin Receptor Common gamma SubunitPdcd1 protein, mouseProgrammed Cell Death 1 ReceptorTransforming Growth Factor beta2Transforming Growth Factor beta3

Identifiers

PMID33647370
PMCPMC8286289
OpenAlexW3135567419

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.