ArticlePLoS pathogens2021
Symbiotic bracovirus of a parasite manipulates host lipid metabolism via tachykinin signaling.
Article in PLoS pathogens, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 46 citations in OpenAlex.
- Transforming hosts into nurseries and nutrients: strategic manipulation by endoparasitoid wasps.Journal of advanced research · 2026Review
- Systematic profiling of nudivirus-like genes reveals conserved and differentiated roles in a domesticated endogenous virus.PLoS pathogens · 2026Article
- Cestode infection is linked to transcriptional shifts in neuropeptide signalling and caste-specific ageing pathways in a social insect.BMC genomics · 2026Article
- Parasitic castration by a viral protein tyrosine phosphatase targeting the host cell cycle checkpoint protein Rad9A.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Genomic landscape and genetic manipulation of an ectoparasitoid wasp, Gregopimpla kuwanae.Communications biology · 2026Article
- Baculoviruses hijack host midgut-derived tachykinin to regulate phototactic climbing behavior and promote viral transmission.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Article
- Lipid Metabolism in Parasitoids and Parasitized Hosts.Advances in experimental medicine and biology · 2026Review
- Regulation of lipid metabolism in Spodoptera frugiperda by the symbiotic bracovirus of the gregarious parasitoid Cotesia ruficrus.PLoS pathogens · 2025Article
- Fruit flies exploit behavioral fever as a defense strategy against parasitic insects.Science advances · 2025Article
- Integration of transcriptomic and proteomic data uncovers the nutritional requirement of the immature development of an endoparasitoid wasp.Scientific reports · 2025Article
- A symbiotic gene stimulates aggressive behavior favoring the survival of parasitized caterpillars.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Symbiotic bracovirus of a parasite modulate host ecdysis process.Cellular and molecular life sciences : CMLS · 2025Article
- Stage-specific metabolic allocation: nutrient investment strategies duringFrontiers in nutrition · 2025Article
- Baculoviruses manipulate host lipid metabolism via adipokinetic hormone signaling to induce climbing behavior.PLoS pathogens · 2025Article
- Transcriptomic Insights into Host Metabolism and Immunity Changes after Parasitization byInsects · 2024Article
- Parasitoid Serpins Evolve Novel Functions to Manipulate Host Homeostasis.Molecular biology and evolution · 2023Article
- Multiomic interpretation of fungus-infected ant metabolomes during manipulated summit disease.Scientific reports · 2023Article
- Parasitism causes changes in caterpillar odours and associated bacterial communities with consequences for host-location by a hyperparasitoid.PLoS pathogens · 2023Article
- Host Transcriptome Analysis ofInsects · 2023Article
Corrections and comments
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Authors and funding
11 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Parasites alter host energy homeostasis for their own development, but the mechanisms underlying this phenomenon remain largely unknown. Here, we show that Cotesia vestalis, an endoparasitic wasp of Plutella xylostella larvae, stimulates a reduction of host lipid levels. This process requires excess secretion of P. xylostella tachykinin (PxTK) peptides from enteroendocrine cells (EEs) in the midgut of the parasitized host larvae. We found that parasitization upregulates PxTK signaling to suppress lipogenesis in midgut enterocytes (ECs) in a non-cell-autonomous manner, and the reduced host lipid level benefits the development of wasp offspring and their subsequent parasitic ability. We further found that a C. vestalis bracovirus (CvBV) gene, CvBV 9-2, is responsible for PxTK induction, which in turn reduces the systemic lipid level of the host. Taken together, these findings illustrate a novel mechanism for parasite manipulation of host energy homeostasis by a symbiotic bracovirus gene to promote the development and increase the parasitic efficiency of an agriculturally important wasp species.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.