Evidence map›Paper›PMID 33646750›Full record

ArticleBiochemistry2021

The Charge Distribution on a Protein Surface Determines Whether Productive or Futile Encounter Complexes Are Formed.

Antonella Di Savino, Johannes M Foerster, G Matthias Ullmann, Marcellus Ubbink

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biochemistry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.6field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 2 countries.

Antonella Di SavinoLeiden University, Institute of Chemistry, Einsteinweg 55, 2333 CC Leiden, The Netherlands.
Johannes M FoersterUniversity of Bayreuth, Computational Biochemistry, Universitätsstraße 30, NW I, 95447 Bayreuth, Germany.ORCID 0000-0003-0442-9413
G Matthias UllmannUniversity of Bayreuth, Computational Biochemistry, Universitätsstraße 30, NW I, 95447 Bayreuth, Germany.ORCID 0000-0002-6350-798X
Marcellus UbbinkLeiden University, Institute of Chemistry, Einsteinweg 55, 2333 CC Leiden, The Netherlands.ORCID 0000-0002-2615-6914
Leiden University · NLUniversity of Bayreuth · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Protein complex formation depends strongly on electrostatic interactions. The distribution of charges on the surface of redox proteins is often optimized by evolution to guide recognition and binding. To test the degree to which the electrostatic interactions between cytochrome

Indexed as

Monte Carlo MethodStatic ElectricityBinding SitesCytochrome-c PeroxidaseCytochromes cElectron TransportModels, MolecularOxidation-ReductionProtein ConformationSaccharomyces cerevisiaeCytochrome-c PeroxidaseCytochromes c

Identifiers

PMID33646750
PMCPMC8041253
OpenAlexW3134663022

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.