ArticleBrain imaging and behavior2021
Brainstem substructures and cognition in prodromal Alzheimer's disease.
Article in Brain imaging and behavior, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- Daily biofeedback to modulate heart rate oscillations affects structural volume in hippocampal subregions targeted by the locus coeruleus in older adults but not younger adults.Neurobiology of aging · 2023Trial
- A phase II study repurposing atomoxetine for neuroprotection in mild cognitive impairment.Brain : a journal of neurology · 2022Trial
- Cerebellar Contributions to Cognitive Affective Function and Postural Tremor in Neurological Wilson's Disease.Cerebellum (London, England) · 2026Article
- White matter hyperintensities, cognitive decline and dementia risk in a community- dwelling cohort of northern Manhattan.Research square · 2026Article
- Long-Term Postdeployment Clinical Subtypes of Risk and Resiliency in Brain Injury and Neurodegeneration.JAMA network open · 2025Article
- Midbrain degeneration triggers astrocyte reactivity and tau pathology in experimental Alzheimer's Disease.Molecular neurodegeneration · 2025Article
- Reductions in brainstem volume as a key macrostructural indicator in at-risk populations for Alzheimer's disease.Alzheimer's research & therapy · 2025Article
- Memory reconsolidation: a proposed change mechanism for the arts therapies.Frontiers in cognition · 2025Article
- Pupil-linked arousal, cortical activity, and cognition in Alzheimer's disease.Brain communications · 2025Article
- Structural and microstructural changes in white and gray matter across the Alzheimer's disease continuum.Frontiers in aging neuroscience · 2025Review
- Greater physical fitness (Acta physiologica (Oxford, England) · 2024Article
- Detection of APP gene recombinant in human blood plasma.Scientific reports · 2023Article
- Daily biofeedback to modulate heart rate oscillations affects structural volume in hippocampal subregions targeted by the locus coeruleus in older adults but not younger adults.medRxiv : the preprint server for health sciences · 2023Article
- Dietary Tyrosine Intake (FFQ) Is Associated with Locus Coeruleus, Attention and Grey Matter Maintenance: An MRI Structural Study on 398 Healthy Individuals of the Berlin Aging Study-II.The journal of nutrition, health & aging · 2023Article
- Brain structural parameters correlate with University Selection Test outcomes in Chilean high school graduates.Scientific reports · 2022Article
- Associations Between Brainstem Volume and Alzheimer's Disease Pathology in Middle-Aged Individuals of the Framingham Heart Study.Journal of Alzheimer's disease : JAD · 2022Article
- Development of a system to analyze oral frailty associated with Alzheimer's disease using a mouse model.Frontiers in aging neuroscience · 2022Article
- A structural connectivity atlas of limbic brainstem nuclei.Frontiers in neuroimaging · 2022Article
- Noradrenergic modulation of rhythmic neural activity shapes selective attention.Trends in cognitive sciences · 2022Review
- Noradrenaline in the aging brain: Promoting cognitive reserve or accelerating Alzheimer's disease?Seminars in cell & developmental biology · 2021Review
Corrections and comments
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Authors and funding
5 authors.
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Abstract
Neuropathological research suggests the tau pathology of Alzheimer's disease may originate in brainstem nuclei, yet it remains unknown whether tau-mediated degeneration of brainstem nuclei influences cognitive impairment in prodromal Alzheimer's disease. The present study examined cognitive domains impacted in prodromal Alzheimer's disease and brainstem substructure volume in cognitively normal older adults (n = 814) and those with mild cognitive impairment (n = 542). Subsamples of cognitively normal (n = 112) and mild cognitive impairment (n = 202) also had cerebrospinal fluid Alzheimer's disease biomarker characterization. Region-of-interest and voxel-level analyses related whole brainstem, midbrain, pons, and locus coeruleus volumes to cognition with multiple linear regression models corrected for age, sex, education, apolipoprotein-ε4 carrier status, and MRI magnet strength. Within mild cognitive impairment participants, smaller midbrain and locus coeruleus volumes were significantly related to poorer performance on tests of attention and executive function, and the relationship between locus coeruleus volume and executive abilities remained significant in the mild cognitive impairment subsample with biomarker-confirmed Alzheimer's disease. A brainstem-masked voxel-wise regression further demonstrated an association between locus coeruleus volume and executive abilities. Brainstem volumes were not significantly related to memory processes. Study findings implicate midbrain and locus coeruleus volume in attention and executive deficits in mild cognitive impairment. Together with prior neuropathological studies, our data suggest a link between Alzheimer's disease-related degeneration of brainstem nuclei and cognitive deficits in prodromal Alzheimer's disease.
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