Evidence map›Paper›PMID 33646480›Full record

ArticleResearch on child and adolescent psychopathology2021

Distinct Patterns of Impaired Cognitive Control Among Boys and Girls with ADHD Across Development.

Alyssa DeRonda, Yi Zhao, Karen E Seymour, Stewart H Mostofsky, Keri S Rosch

Open access · greenAbstract read
In one paragraph

Article in Research on child and adolescent psychopathology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
1.8field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it, 20 citations in OpenAlex.

  1. Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Alyssa DeRondaCenter for Neurodevelopmental and Imaging Research, Kennedy Krieger Institute, Baltimore, MD, USA.
Yi ZhaoDepartment of Biostatistics, Indiana University School of Medicine, Indianapolis, IN, USA.
Karen E SeymourCenter for Neurodevelopmental and Imaging Research, Kennedy Krieger Institute, Baltimore, MD, USA.
Stewart H MostofskyCenter for Neurodevelopmental and Imaging Research, Kennedy Krieger Institute, Baltimore, MD, USA.
Keri S RoschCenter for Neurodevelopmental and Imaging Research, Kennedy Krieger Institute, Baltimore, MD, USA. rosch@kennedykrieger.org.ORCID 0000-0002-1923-2552
Kennedy Krieger Institute · USIndiana University School of Medicine

Funding

Sleep and Circadian Dysfunction, Brain and Neurobehavioral Development in AutismP50HD103538 · NICHD · HUGO W. MOSER RES INST KENNEDY KRIEGER · PI Stewart H Mostofsky · 2020 to 2026
$9.9M
Neurology of Deficient Response Control in ADHDR01MH085328 · NIMH · HUGO W. MOSER RES INST KENNEDY KRIEGER · PI MOSTOFSKY, STEWART H · 2009 to 2019
$7.3M
Anomalous Motor Physiology In ADHDR01MH078160 · NIMH · HUGO W. MOSER RES INST KENNEDY KRIEGER · PI MOSTOFSKY, STEWART H · 2006 to 2024
$5.8M
Neurobehavioral Correlates of Frustration in Children with ADHDK23MH107734 · NIMH · JOHNS HOPKINS UNIVERSITY · PI SEYMOUR, KAREN E · 2015 to 2019
$815k
Delay Discounting in Children with ADHD: Neuroimaging and Behavioral CorrelatesK23MH101322 · NIMH · HUGO W. MOSER RES INST KENNEDY KRIEGER · PI ROSCH, KERI SHIELS · 2013 to 2017
$735k
Examination of developmental trajectories of cognitive, motor and emotional control in relation to sex differences in psychopathologyR03MH119457 · NIMH · HUGO W. MOSER RES INST KENNEDY KRIEGER · PI ROSCH, KERI SHIELS · 2020 to 2021
$162k
NICHD NIH HHS P50 HD103538NIMH NIH HHS K23 MH101322NIMH NIH HHS K23 MH107734NIMH NIH HHS R01 MH078160NIMH NIH HHS R01 MH085328NIMH NIH HHS R03 MH119457
6 · The paper itself

Abstract

This study examined whether girls and boys with ADHD show similar impairments in cognitive control from childhood into adolescence and the developmental relationship between cognitive control and ADHD symptoms. Participants include 8-17-year-old children with ADHD (n = 353, 104 girls) and typically developing (TD) controls (n = 241, 86 girls) with longitudinal data obtained from n = 137. Participants completed two go/no-go (GNG) tasks that varied in working memory demand. Linear mixed-effects models were applied to compare age-related changes in cognitive control for each GNG task among girls and boys with ADHD and TD controls and in relation to ADHD symptoms. Boys with ADHD showed impaired response inhibition and increased response variability across tasks. In contrast, girls with ADHD showed impaired response inhibition only with greater working memory demands whereas they displayed increased response variability regardless of working memory demands. Analysis of age-related change revealed that deficits in cognitive control under minimal working memory demands increase with age among girls with ADHD and decrease with age among boys with ADHD. In contrast, deficits in cognitive control with greater working memory demands decrease with age among both boys and girls with ADHD compared to TD peers. Among children with ADHD poor response inhibition during childhood predicted inattentive symptoms in adolescence and was associated with less age-related improvement in inattentive symptoms. These findings suggest that girls and boys with ADHD show differential impairment in cognitive control across development and response inhibition in childhood may be an important predictor of ADHD symptoms in adolescence.

Indexed as

Attention Deficit Disorder with HyperactivityCognitive DysfunctionAdolescentChildCognitionFemaleHumansMaleMemory, Short-TermADHDCognitive controlDevelopmentResponse inhibitionSex differencesVariability

Identifiers

PMID33646480
PMCPMC8159847
OpenAlexW3135588376

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.