Evidence map›Paper›PMID 33646470›Full record

ArticleJournal of assisted reproduction and genetics2021

A novel embryo quality scoring system to compare groups of embryos at different developmental stages.

Satoshi Mizuno, Hiroshi Matsumoto, Shu Hashimoto, Manjula Brahmajosyula, Aya Ohgaki, Sachiyo Tarui, Mari Matoba, Manabu Satoh, Aisaku Fukuda, Yoshiharu Morimoto

Abstract read
In one paragraph

Article in Journal of assisted reproduction and genetics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Satoshi MizunoIVF Osaka Clinic, Higashi-Osaka, Osaka, 577-0012, Japan. mizuno@ivfosaka.com.ORCID http://orcid.org/0000-0003-3275-204X
Hiroshi MatsumotoIVF Osaka Clinic, Higashi-Osaka, Osaka, 577-0012, Japan.
Shu HashimotoIVF Namba Clinic, Osaka, 550-0015, Japan.
Manjula BrahmajosyulaHORAC Grand Front Osaka Clinic, Osaka, 530-0011, Japan.
Aya OhgakiIVF Osaka Clinic, Higashi-Osaka, Osaka, 577-0012, Japan.
Sachiyo TaruiIVF Osaka Clinic, Higashi-Osaka, Osaka, 577-0012, Japan.
Mari MatobaHORAC Grand Front Osaka Clinic, Osaka, 530-0011, Japan.
Manabu SatohIVF Namba Clinic, Osaka, 550-0015, Japan.
Aisaku FukudaIVF Osaka Clinic, Higashi-Osaka, Osaka, 577-0012, Japan.
Yoshiharu MorimotoHORAC Grand Front Osaka Clinic, Osaka, 530-0011, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo construct a new embryonic quality scoring system to compare groups of embryos at different developmental stages.

methodsBased on a hypothesis that the implantation potential of any embryo in an ovum pickup (OPU) cycle remains the same at any stage of development, be it day 2, 3, or 5, a new embryo quality scoring (EQS) system was designed. It was based on the analysis of the clinical results of 1610 single embryo transfers. We validated this scoring system in the comparison of embryonic quality between groups by evaluating the mean scores calculated at day 2, day 3, and day 5 for 957 embryos (150 cycles) from 3 different groups. We then compared EQSs of patients with pregnancy favorable factors (group A) such as young age and high AMH levels, with the patients with contra features (group B).

resultsWe confirmed that each mean EQS assessed at different stages of embryonic development within the same group was similar. The mean EQSs on day 3 and day 5 in group A were significantly higher than the mean EQSs on days 2, 3, and 5 in group B.

conclusionThe novel EQS system proposed by us enables embryonic quality comparison between groups of embryos at different developmental stages.

Indexed as

Embryonic DevelopmentFertilization in VitroAdultBlastocystEmbryo ImplantationEmbryo, MammalianEmbryo TransferFemaleHumansPregnancyPregnancy RateSingle Embryo TransferSperm Injections, IntracytoplasmicEmbryo quality assessmentEmbryo quality comparisonEmbryo quality scoringNumerical score

Identifiers

PMID33646470
PMCPMC8190420

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.