Evidence map›Paper›PMID 33646444›Full record

ArticleActa neurochirurgica2022

Cerebrospinal fluid diversion and outcomes for lung cancer patients with leptomeningeal carcinomatosis.

Yan-Hua Su, Chi-Lu Chiang, Huai-Che Yang, Yong-Sin Hu, Yu-Wei Chen, Yung-Hung Luo, Ching-Jen Chen, Hsiu-Mei Wu, Chung-Jung Lin, Cheng-Chia Lee

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In one paragraph

Article in Acta neurochirurgica, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 1 pooled it
1.2field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 1 synthesis or guideline pooled it, 16 citations in OpenAlex.

  1. Pooled it
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  6. Review
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  11. Advances in Intraoperative Flow Cytometry.International journal of molecular sciences · 2022
    Review
  12. State-of-the-Art Molecular Oncology of Lung Cancer in Taiwan.International journal of molecular sciences · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 2 countries.

Yan-Hua SuDepartment of Neurosurgery, Neurological Institute, Taipei Veterans General Hospital, Taipei, Taiwan.
Chi-Lu ChiangSchool of Medicine, National Yang Ming Chiao Tung University, Hsinchu, 30010, Taiwan.
Huai-Che YangDepartment of Neurosurgery, Neurological Institute, Taipei Veterans General Hospital, Taipei, Taiwan.
Yong-Sin HuSchool of Medicine, National Yang Ming Chiao Tung University, Hsinchu, 30010, Taiwan.
Yu-Wei ChenDepartment of Neurosurgery, Neurological Institute, Taipei Veterans General Hospital, Taipei, Taiwan.
Yung-Hung LuoSchool of Medicine, National Yang Ming Chiao Tung University, Hsinchu, 30010, Taiwan.
Ching-Jen ChenDepartment of Neurological Surgery, University of Virginia Health System, Charlottesville, Virginia, USA.
Hsiu-Mei WuSchool of Medicine, National Yang Ming Chiao Tung University, Hsinchu, 30010, Taiwan.
Chung-Jung LinSchool of Medicine, National Yang Ming Chiao Tung University, Hsinchu, 30010, Taiwan.
Cheng-Chia LeeDepartment of Neurosurgery, Neurological Institute, Taipei Veterans General Hospital, Taipei, Taiwan. yfnaughty@gmail.com.ORCID 0000-0003-4691-2913
National Yang Ming Chiao Tung University · TWTaipei Veterans General Hospital · TWUniversity of Virginia Health System · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo investigate the outcomes of cerebrospinal fluid (CSF) diversion in lung cancer patients with leptomeningeal carcinomatosis (LMC).

methodsA retrospective review of consecutive lung cancer patients with LMC suffering from increased intracranial pressure (IICP) and hydrocephalus between February 2017 and February 2020. We evaluated the survival benefit of CSF diversion surgery and assessed the outcomes of treatments administered post-LMC in terms of overall survival and shunt-related complications.

resultsThe study cohort included 50 patients (median age: 59 years). Ventricular peritoneal (VP) shunts were placed in 33 patients, and lumbar peritoneal (LP) shunts were placed in 7 patients. Programmable shunts were placed in 36 patients. Shunt adjustment was performed in 19 patients. Kaplan-Meier analysis revealed that shunt placement increased overall survival from 1.95 months to 6.21 months (p = 0.0012) and increased Karnofsky Performance Scores (KPS) from 60 to 70. Univariate analysis revealed no difference between VP or LP shunts in terms of survival. No differences in post-shunt systemic treatments (tyrosine kinase inhibitors (TKIs) or systemic treatments) were observed in overall survival. Shunt-related complications were noted in 7 patients, including shunt obstruction (n = 4), infection (n = 1), and over-drainage (n = 2).

conclusionCSF diversion (VP or LP shunt) appears to be an effective and safe treatment for lung cancer patients with LMC and hydrocephalus. Programmable shunts should be considered for complex cases, which commonly require pressure adjustments as the disease progresses.

Indexed as

HydrocephalusLung NeoplasmsMeningeal CarcinomatosisCerebrospinal Fluid ShuntsHumansMiddle AgedRetrospective StudiesTreatment OutcomeVentriculoperitoneal ShuntBrain metastasisEGFR mutationHydrocephalusLeptomeningeal carcinomatosisLung cancerShunt

Identifiers

PMID33646444
OpenAlexW3135875032

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.