Evidence map›Paper›PMID 33646423›Full record

ArticleEuropean journal of applied physiology2021

The effects of normoxic endurance exercise on erythropoietin (EPO) production and the impact of selective β

Rod J Azadan, Nadia H Agha, Hawley E Kunz, Forrest L Baker, Preteesh L Mylabathula, Tracy A Ledoux, Daniel P O'Connor, Charles R Pedlar, Richard J Simpson

Abstract read
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In one paragraph

Article in European journal of applied physiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 56% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 2 countries.

Rod J AzadanLaboratory of Integrated Physiology, Department of Health and Human Performance, University of Houston, 3875 Holman Street, Houston, TX, 77204, USA.ORCID http://orcid.org/0000-0001-7160-1557
Nadia H AghaDepartment of Molecular Physiology and Biophysics, Baylor College of Medicine, Houston, TX, USA.ORCID http://orcid.org/0000-0001-5011-766X
Hawley E KunzDivision of Endocrinology, Diabetes, Metabolism, and Nutrition, Mayo Clinic, Rochester, MN, USA.ORCID http://orcid.org/0000-0002-4291-4455
Forrest L BakerLaboratory of Integrated Physiology, Department of Health and Human Performance, University of Houston, 3875 Holman Street, Houston, TX, 77204, USA.ORCID http://orcid.org/0000-0001-5338-7905
Preteesh L MylabathulaLaboratory of Integrated Physiology, Department of Health and Human Performance, University of Houston, 3875 Holman Street, Houston, TX, 77204, USA.ORCID http://orcid.org/0000-0002-8428-0251
Tracy A LedouxLaboratory of Integrated Physiology, Department of Health and Human Performance, University of Houston, 3875 Holman Street, Houston, TX, 77204, USA.ORCID http://orcid.org/0000-0003-4935-4822
Daniel P O'ConnorLaboratory of Integrated Physiology, Department of Health and Human Performance, University of Houston, 3875 Holman Street, Houston, TX, 77204, USA.ORCID https://orcid.org/0000-0001-9750-2864
Charles R PedlarFaculty of Sport, Health and Applied Science, St Mary's University, Twickenham, England, UK.ORCID http://orcid.org/0000-0002-3075-9101
Richard J SimpsonLaboratory of Integrated Physiology, Department of Health and Human Performance, University of Houston, 3875 Holman Street, Houston, TX, 77204, USA. rjsimpson@arizona.edu.ORCID http://orcid.org/0000-0002-7064-6881
University of Arizona · USUniversity of Houston · USBaylor College of Medicine · USEnglish Institute of Sport · GBMayo Clinic in Arizona · US

Funding

NIH HHS CA197527-01A1
6 · The paper itself

Abstract

purposeHabitual endurance exercise results in increased erythropoiesis, which is primarily controlled by erythropoietin (EPO), yet studies demonstrating upregulation of EPO via a single bout of endurance exercise have been equivocal. This study compares the acute EPO response to 30 min of high versus 90 min of moderate-intensity endurance exercise and whether that response can be upregulated via selective adrenergic receptor blockade.

methodsUsing a counterbalanced, cross-over design, fifteen participants (age 28 ± 8) completed two bouts of running (30-min, high intensity vs 90-min, moderate intensity) matched for overall training stress. A separate cohort of fourteen participants (age 31 ± 6) completed three bouts of 30-min high-intensity cycling after ingesting the preferential β

resultsNo detectable EPO response was observed during or after high intensity running, however, in the moderate-intensity trial EPO was significantly elevated at both during-exercise timepoints (+ 6.8% ± 2.3% at 15 min and + 8.7% ± 2.2% at 60 min). No significant change in EPO was observed post-cycling or between the trials involving βAR blockade.

conclusionNeither training mode (running or cycling), nor beta-blockade significantly influenced the EPO response to 30 min of high-intensity exercise, however, 90 min of moderate-intensity running elevated EPO during exercise, returning to baseline immediately post-exercise. Identifying the optimal mode, duration and intensity required to evoke an EPO response to exercise may help tailor exercise prescriptions designed to maximize EPO response for both performance and clinical applications.

Indexed as

Adrenergic beta-1 Receptor AntagonistsAdrenergic beta-AntagonistsAdultBicyclingBisoprololCross-Over StudiesErythropoietinFemaleHumansMaleNadololPhysical EnduranceRunningUp-RegulationAdrenergic beta-1 Receptor AntagonistsAdrenergic beta-AntagonistsBisoprololErythropoietinNadololBeta blockadeEndurance exerciseEPOErythropoietinRunningβAR

Identifiers

PMID33646423
OpenAlexW3134943926

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.