Evidence map›Paper›PMID 33646363›Full record

ReviewDer Pathologe2021

[COVID-19 and the central and peripheral nervous system].

N Ritschel, H Radbruch, C Herden, N Schneider, C Dittmayer, J Franz, C Thomas, G Silva Boos, A Pagenstecher, W Schulz-Schaeffer and 10 more

Open access · hybridAbstract readReview
In one paragraph

Review in Der Pathologe, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.5field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 14 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors at 5 institutions in 1 country.

N RitschelInstitut für Neuropathologie, Justus-Liebig-Universität Gießen, Arndtstraße 16, 35392, Gießen, Deutschland.
H RadbruchInstitut für Neuropathologie, Charité - Universitätsmedizin Berlin, Berlin, Deutschland.
C HerdenInstitut für Veterinär-Pathologie, Justus-Liebig-Universität Gießen, Gießen, Deutschland.
N SchneiderInstitut für Medizinische Informatik, Justus-Liebig-Universität Gießen, Gießen, Deutschland.
C DittmayerInstitut für Neuropathologie, Charité - Universitätsmedizin Berlin, Berlin, Deutschland.
J FranzInstitut für Neuropathologie, Universitätsmedizin Göttingen, Göttingen, Deutschland.
C ThomasInstitut für Neuropathologie, Universitätsmedizin Göttingen, Göttingen, Deutschland.
G Silva BoosInstitut für Veterinär-Pathologie, Justus-Liebig-Universität Gießen, Gießen, Deutschland.
A PagenstecherAbteilung für Neuropathologie, Philipps-Universität Marburg, Marburg, Deutschland.
W Schulz-SchaefferInstitut für Neuropathologie, Universität des Saarlandes, Homburg, Deutschland.
C StadelmannInstitut für Neuropathologie, Universitätsmedizin Göttingen, Göttingen, Deutschland.
M GlatzelInstitut für Neuropathologie, Universitätsklinikum Hamburg-Eppendorf (UKE), Hamburg, Deutschland.
F L HeppnerInstitut für Neuropathologie, Charité - Universitätsmedizin Berlin, Berlin, Deutschland.
J WeisInstitut für Neuropathologie, Universitätsklinikum der RWTH Aachen, Aachen, Deutschland.
K SohrabiFachbereich Gesundheit, Technische Hochschule Mittelhessen, Gießen, Deutschland.
A SchänzerInstitut für Neuropathologie, Justus-Liebig-Universität Gießen, Arndtstraße 16, 35392, Gießen, Deutschland.
A NémethInstitut für Neuropathologie, Justus-Liebig-Universität Gießen, Arndtstraße 16, 35392, Gießen, Deutschland.
T AckerInstitut für Neuropathologie, Justus-Liebig-Universität Gießen, Arndtstraße 16, 35392, Gießen, Deutschland. till.acker@patho.med.uni-giessen.de.
DGNN-Taskforce „CNS-COVID19“
„DEFEAT PANDEMIcs – Neuropathologische Referenzdiagnostik bei COVID-19“
Justus-Liebig-Universität Gießen · DEPhilipps University of Marburg · DEUniversität Hamburg · DEUniversitätsmedizin Göttingen · DEGerman Center for Neurodegenerative Diseases · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The health effects of coronavirus disease 2019 (COVID-19) caused by the infection of SARS-CoV‑2 (severe acute respiratory syndrome coronavirus 2) are becoming increasingly clear as the pandemic spreads. In addition to the lungs, other organs are also affected, which can significantly influence morbidity and mortality. In particular, neurological symptoms involving the central nervous system can lead to acute or long-term consequences. The mechanisms of this neuropathogenesis of SARS-CoV‑2 infection and its relation to acute and chronic neurological symptoms are the subject of current studies investigating a potential direct and indirect viral infection of the nervous system. The following review summarizes the current status of neuropathological manifestations, molecular pathogenesis, possible infection pathways in the nervous system, and systemic effects. In addition, an overview of the Germany-wide CNS-COVID19 registry and collaborations is presented, which should contribute to a better understanding of the neurological symptoms of COVID-19.

Indexed as

COVID-19GermanyHumansPandemicsPeripheral Nervous SystemSARS-CoV-2AutopsyNervous systemNeuropathologyRegistrySARS-CoV-2

Identifiers

PMID33646363
PMCPMC7919253
OpenAlexW3134650551

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.