Evidence map›Paper›PMID 33646174›Full record

ReviewJournal of neuromuscular diseases2021

The Role of Nutrition and Physical Activity as Trigger Factors of Paralytic Attacks in Primary Periodic Paralysis.

Natasha Lervaag Welland, Helge Hæstad, Hanne Ludt Fossmo, Kaja Giltvedt, Kristin Ørstavik, Marianne Nordstrøm

Open access · bronzeAbstract readReview
In one paragraph

Review in Journal of neuromuscular diseases, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.9field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 14 citations in OpenAlex.

  1. Lifestyle and dietary measures in Periodic Paralyses.Acta myologica : myopathies and cardiomyopathies : official journal of the Mediterranean Society of Myology · 2026
    Review
  2. Thyrotoxic Hypokalemic Periodic Paralysis: Pathophysiological Mechanisms.Endocrinology and metabolism (Seoul, Korea) · 2025
    Review
  3. Exploring self-management of diet and physical activity inJournal of neuromuscular diseases · 2025
    Article
  4. Hypokelemic Periodic Paralysis in Pregnancy-A Rare Case Study.Journal of obstetrics and gynaecology of India · 2025
    Article
  5. The network of cardiac KNaunyn-Schmiedeberg's archives of pharmacology · 2024
    Review
  6. Article
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Natasha Lervaag WellandFrambu Resource Centre for Rare Disorders (Frambu), Siggerud, Norway.
Helge HæstadNational Neuromuscular Centre (NMK), University Hospital of North Norway, Norway.
Hanne Ludt FossmoUnit for Congenital and Hereditary Neuromuscular Disorders (EMAN), Department of Neurology, Oslo University Hospital, Oslo, Norway.
Kaja GiltvedtFrambu Resource Centre for Rare Disorders (Frambu), Siggerud, Norway.
Kristin ØrstavikUnit for Congenital and Hereditary Neuromuscular Disorders (EMAN), Department of Neurology, Oslo University Hospital, Oslo, Norway.
Marianne NordstrømFrambu Resource Centre for Rare Disorders (Frambu), Siggerud, Norway.
Oslo University Hospital · NOUniversity Hospital of North Norway · NO

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPrimary periodic paralysis (PPP) are rare inherited neuromuscular disorders including Hypokalemic periodic paralysis (HypoPP), Hyperkalemic periodic paralysis (HyperPP) and Andersen-Tawil syndrome (ATS) characterised by attacks of weakness or paralysis of skeletal muscles. Limited effective pharmacological treatments are available, and avoidance of lifestyle related triggers seems important.

objectiveOur aim was to search and assess the scientific literature for information on trigger factors related to nutrition and physical activity in PPP.

methodsWe searched Ovid Medline and Embase database for scientific papers published between January 1, 1990, to January 31, 2020.

resultsWe did not identify published observation or intervention studies evaluating effect of lifestyle changes on attacks. Current knowledge is based on case-reports, expert opinions, and retrospective case studies with inadequate methods for description of nutrition and physical activity. In HypoPP, high carbohydrate and salt intake, over-eating, alcohol, dehydration, hard physical activity, and rest after exercise are frequently reported triggers. Regarding HyperPP, fasting, intake of potassium, alcohol, cold foods or beverages, physical activity, and rest after exercise are frequently reported triggers. No nutrition related triggers are reported regarding ATS, exercise can however induce ventricular arrhythmias.

conclusionsOur results support that dietary intake and physical activity may play a role in causing paralytic attacks in PPP, although the current scientific evidence is weak. To provide good evidence-based patient care, several lifestyle aspects need to be further assessed and described.

Indexed as

DietExerciseAdolescentAdultAgedAged, 80 and overAndersen SyndromeFemaleHumansMaleMiddle AgedParalyses, Familial PeriodicParalysisYoung AdultAnderson-Tawil syndromedietary intakeHyperkalemic periodic paralysisHypokalemic periodic paralysisphysical activityPrimary periodic paralysis

Identifiers

PMID33646174
PMCPMC8385530
OpenAlexW3134788189

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.