Evidence map›Paper›PMID 33645592›Full record

ArticleChemical communications (Cambridge, England)2021

A reactive peptide interface for site-selective cysteine bioconjugation.

Suan Tuang, Diomedes Dieppa-Matos, Chi Zhang, Christopher R Shugrue, Peng Dai, Andrei Loas, Bradley L Pentelute

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Chemical communications (Cambridge, England), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Peptide Tags for Site-Selective Nonenzymatic Covalent Modification of Proteins.Journal of peptide science : an official publication of the European Peptide Society · 2025
    Review
  2. Review
  3. Fast Cysteine Bioconjugation Chemistry.Chemistry (Weinheim an der Bergstrasse, Germany) · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Suan TuangMassachusetts Institute of Technology, Department of Chemistry, 77 Massachusetts Avenue, Cambridge, MA 02139, USA.
Diomedes Dieppa-Matos
Chi Zhang
Christopher R Shugrue
Peng Dai
Andrei Loas
Bradley L Pentelute

Funding

Cysteine ArylationR01GM110535 · NIGMS · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI PENTELUTE, BRADLEY LETHER · 2014 to 2018
$1.5M
Acquisition of Octet Biolayer Interferometry system for MIT biophysics facilityS10OD016326 · OD · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI IMPERIALI, BARBARA · 2014 to 2014
$180k
Site-Selective Modification of Peptides and Proteins through Noncovalent InteractionsF32GM133073 · NIGMS · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI SHUGRUE, CHRISTOPHER RYAN · 2019 to 2020
$126k
NIGMS NIH HHS F32 GM133073NIGMS NIH HHS R01 GM110535NIH HHS S10 OD016326
6 · The paper itself

Abstract

We report aqueous, site-selective modification of proteins using a reactive peptide interface comprising a nine-residue sequence. This interface is the fastest (second-order rate constant of 152 M

Indexed as

AntibodiesCysteinePeptidesProteinsStaining and LabelingWaterAntibodiesCysteinePeptidesProteinsWater

Identifiers

PMID33645592
PMCPMC8048384

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.