Evidence map›Paper›PMID 33645438›Full record

ArticleGut microbes

Gut microbiota shape the inflammatory response in mice with an epithelial defect.

Ran Wang, Md Moniruzzaman, Kuan Yau Wong, Percival Wiid, Alexa Harding, Rabina Giri, Wendy Hui Tong, Jackie Creagh, Jakob Begun, Michael A McGuckin and 1 more

Open access · goldAbstract read
In one paragraph

Article in Gut microbes. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 27 citations in OpenAlex.

  1. Review
  2. Article
  3. International journal of molecular sciences · 2026
    Article
  4. Article
  5. Review
  6. Advances in Crohn's Disease: A Comprehensive Review of Pathophysiology, Diagnosis, and Emerging Therapeutics.JGH open : an open access journal of gastroenterology and hepatology · 2026
    Review
  7. Review
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Review
  15. Early subclinical stages of the inflammatory bowel diseases: insights from human and animal studies.American journal of physiology. Gastrointestinal and liver physiology · 2025
    Review
  16. Review
  17. Article
  18. Article
  19. Recombinant probioticFrontiers in microbiology · 2024
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 1 country.

Ran WangImmunopathology Group, Mater Research Institute - The University of Queensland, Translational Research Institute, Brisbane, Australia.
Md MoniruzzamanImmunopathology Group, Mater Research Institute - The University of Queensland, Translational Research Institute, Brisbane, Australia.
Kuan Yau WongImmunopathology Group, Mater Research Institute - The University of Queensland, Translational Research Institute, Brisbane, Australia.
Percival WiidImmunopathology Group, Mater Research Institute - The University of Queensland, Translational Research Institute, Brisbane, Australia.
Alexa HardingImmunopathology Group, Mater Research Institute - The University of Queensland, Translational Research Institute, Brisbane, Australia.
Rabina GiriInflammatory Bowel Disease Group, Mater Research Institute - The University of Queensland, Translational Research Institute, Brisbane, Australia.
Wendy Hui TongImmunopathology Group, Mater Research Institute - The University of Queensland, Translational Research Institute, Brisbane, Australia.
Jackie CreaghImmunopathology Group, Mater Research Institute - The University of Queensland, Translational Research Institute, Brisbane, Australia.
Jakob BegunInflammatory Bowel Disease Group, Mater Research Institute - The University of Queensland, Translational Research Institute, Brisbane, Australia.
Michael A McGuckinImmunopathology Group, Mater Research Institute - The University of Queensland, Translational Research Institute, Brisbane, Australia.
Sumaira Z HasnainImmunopathology Group, Mater Research Institute - The University of Queensland, Translational Research Institute, Brisbane, Australia.
Mater Research · AUTranslational Research Institute · AUUniversity of Queensland · AUMater Health Services · AUMelbourne Health · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Intestinal epithelial cell endoplasmic reticulum (ER) stress has been implicated in intestinal inflammation. It remains unclear whether ER stress is an initiator of or a response to inflammation.

Indexed as

Gastrointestinal MicrobiomeAnimalsColitis, UlcerativeCytokinesEndoplasmic Reticulum StressEpithelial CellsGerm-Free LifeGoblet CellsIntestinal MucosaMaleMiceMucin-2Paneth CellsProtein FoldingCytokinesMuc2 protein, mouseMucin-2epithelial cellsGerm freeInflammationMicrobiotamucin

Identifiers

PMID33645438
PMCPMC7928202
OpenAlexW3134298341

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.