Evidence map›Paper›PMID 33645430›Full record

ArticleGut microbes

Intestinal and systemic inflammation induced by symptomatic and asymptomatic enterotoxigenic

Jessica Brubaker, Xueyan Zhang, A Louis Bourgeois, Clayton Harro, David A Sack, Subhra Chakraborty

Open access · goldAbstract read
In one paragraph

Article in Gut microbes. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.

0numbers the graph read from it
0cells of the map it votes in
39citing papers in PubMed
4.3field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

39 citing papers in PubMed, 51 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Veterinary sciences · 2026
    Article
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  6. Article
  7. Article
  8. Article
  9. Article
  10. Effects ofAnimals : an open access journal from MDPI · 2025
    Article
  11. Modulation of Macrophages TLR4-Mediated Transcriptional Response byInternational journal of molecular sciences · 2025
    Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Dietary Bacteriophage Administration Alleviates EnterotoxigenicInternational journal of molecular sciences · 2024
    Article
  17. Article
  18. Article
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Jessica BrubakerDepartment of International Health, Johns Hopkins Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, USA.
Xueyan ZhangDepartment of International Health, Johns Hopkins Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, USA.
A Louis BourgeoisDepartment of International Health, Johns Hopkins Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, USA.
Clayton HarroDepartment of International Health, Johns Hopkins Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, USA.
David A SackDepartment of International Health, Johns Hopkins Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, USA.
Subhra ChakrabortyDepartment of International Health, Johns Hopkins Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, USA.
Johns Hopkins University · USCenter for Innovation · US

Funding

Natural infection of norovirus and sapovirus in a birth cohort in a Peruvian periurban communityR01AI108695 · NIAID · JOHNS HOPKINS UNIVERSITY · PI CHAKRABORTY, SUBHRA, GILMAN, ROBERT H · 2015 to 2019
$5.0M
The impact of non-dysentery Shigella-associated diarrhea in childrenR01AI153399 · NIAID · JOHNS HOPKINS UNIVERSITY · PI CHAKRABORTY, SUBHRA · 2021 to 2025
$3.2M
The impact of non-dysentery Shigella-associated diarrhea in childrenR56AI153399 · NIAID · JOHNS HOPKINS UNIVERSITY · PI CHAKRABORTY, SUBHRA · 2020 to 2020
$524k
NIAID NIH HHS R01 AI108695NIAID NIH HHS R01 AI153399NIAID NIH HHS R56 AI153399
6 · The paper itself

Abstract

Recent studies have gained a better appreciation of the potential impacts of enteric infections beyond symptomatic diarrhea. It is recognized that infections by several enteropathogens could be associated with growth deficits in children and intestinal and systemic inflammation may play an important underlying role. With enterotoxigenic

Indexed as

Antibodies, BacterialAsymptomatic InfectionsBacterial ToxinsCytokinesDiarrheaEnterotoxigenic Escherichia coliEnterotoxinsEscherichia coli InfectionsEscherichia coli ProteinsFatty Acid-Binding ProteinsFecesFimbriae ProteinsHumansImmunoglobulin AImmunoglobulin GInflammationAntibodies, BacterialBacterial Toxinscolonization factor antigensCytokinesEnterotoxinsEscherichia coli ProteinsFatty Acid-Binding ProteinsFimbriae Proteinsheat-labile enterotoxin, E coliImmunoglobulin AImmunoglobulin GPeroxidasecytokinesETECimmune responseintestinal fatty acid-binding proteinintestinal inflammationmyeloperoxidasesystemic inflammation

Identifiers

PMID33645430
PMCPMC7919917
OpenAlexW3133953292

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.