Evidence map›Paper›PMID 33645260›Full record

ArticleAutism : the international journal of research and practice2021

A co-twin-control study of altered sensory processing in autism.

Janina Neufeld, Mark J Taylor, Karl Lundin Remnélius, Johan Isaksson, Paul Lichtenstein, Sven Bölte

Open access · hybridAbstract readTwin Study
In one paragraph

Article in Autism : the international journal of research and practice, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
2.8field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 30 citations in OpenAlex.

  1. Article
  2. Article
  3. Does Camouflaging Cause Reduced Quality of Life? A Co-Twin Control Study.Journal of autism and developmental disorders · 2026
    Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Diversity-Friendly Initiatives: Substance or Show? The Case of Silent Clapping.Scandinavian journal of child and adolescent psychiatry and psychology · 2025
    Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Modality-specific associations between sensory differences and autistic traits.Autism : the international journal of research and practice · 2023
    Article
  14. Article
  15. Article
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Janina NeufeldKarolinska Institutet, Sweden.ORCID 0000-0002-7743-526X
Mark J TaylorKarolinska Institutet, Sweden.
Karl Lundin RemnéliusKarolinska Institutet, Sweden.ORCID 0000-0002-0270-8358
Johan IsakssonKarolinska Institutet, Sweden.
Paul LichtensteinKarolinska Institutet, Sweden.
Sven BölteKarolinska Institutet, Sweden.ORCID 0000-0002-4579-4970
Karolinska Institutet · SECurtin University · AUUppsala University · SE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

lay abstractIndividuals diagnosed with autism often describe that they process sensory information differently from others, and many experience sensory issues as problematic. For instance, an increased sensitivity to smells or sounds can make participating in social settings challenging. While sensory issues are now part of the diagnostic criteria for autism, they also co-occur with other psychiatric diagnoses such as attention deficit hyperactivity disorder and anxiety disorders. It is unclear to what extent the relationship between autism and alterations in sensory processing are due to genetics or environment. In addition, more research is needed on how autism, as compared to other diagnoses, is associated with sensory issues. Using a twin study, we found that genetic factors influenced self-reported reactivity to sensory stimuli in autism while environmental factors influenced other sensory issues (e.g. difficulties in detecting or differentiating sensory input). Hence, sensory hyper-reactivity might be an early onset core feature of autism, while other domains of alterations in sensory processing might develop later, influenced by the environment. Moreover, autism was more strongly associated with sensory issues related to increased sensitivity/reactivity as compared to other psychiatric diagnoses. However, attention deficit hyperactivity disorder was more strongly related to deficits in detecting/differentiating sensory stimuli and with an increased drive to seek sensory input. Our results indicate that sensory issues are not specific to autism, but that some aspects of altered sensory processing are more relevant for autism than for other diagnoses.

Indexed as

Attention Deficit Disorder with HyperactivityAutism Spectrum DisorderAutistic DisorderAnxiety DisordersHumansPerceptionautism spectrum disordersbehavioral geneticsenvironmental factorssensory processingsensory profiletwin design

Identifiers

PMID33645260
PMCPMC8264631
OpenAlexW3135494116

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.