Evidence map›Paper›PMID 33644996›Full record

ArticleAdvanced healthcare materials2021

In Vivo Printing of Nanoenabled Scaffolds for the Treatment of Skeletal Muscle Injuries.

Jacob P Quint, Azadeh Mostafavi, Yori Endo, Adriana Panayi, Carina S Russell, Atousa Nourmahnad, Chris Wiseman, Laleh Abbasi, Mohamadmahdi Samandari, Amir Sheikhi and 3 more

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PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced healthcare materials, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed, 1 pooled it
6.8field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

38 citing papers in PubMed, 1 synthesis or guideline pooled it, 97 citations in OpenAlex.

  1. Pooled it
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  17. Bioactive materials · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 1 country.

Jacob P QuintDepartment of Mechanical and Materials Engineering, University of Nebraska, Lincoln, NE, 68588, USA.
Azadeh MostafaviDepartment of Mechanical and Materials Engineering, University of Nebraska, Lincoln, NE, 68588, USA.
Yori EndoDivision of Plastic Surgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 02115, USA.
Adriana PanayiDivision of Plastic Surgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 02115, USA.
Carina S RussellDepartment of Mechanical and Materials Engineering, University of Nebraska, Lincoln, NE, 68588, USA.
Atousa NourmahnadDivision of Plastic Surgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 02115, USA.
Chris WisemanDepartment of Mechanical and Materials Engineering, University of Nebraska, Lincoln, NE, 68588, USA.
Laleh AbbasiDepartment of Mechanical and Materials Engineering, University of Nebraska, Lincoln, NE, 68588, USA.
Mohamadmahdi SamandariDepartment of Biomedical Engineering, University of Connecticut, Farmington, CT, 06030, USA.
Amir SheikhiDepartment of Chemical Engineering, Department of Biomedical Engineering, The Pennsylvania State University, State College, University Park, PA, 16802, USA.
Kristo NuutilaDivision of Plastic Surgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 02115, USA.
Indranil SinhaDivision of Plastic Surgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 02115, USA.
Ali TamayolDepartment of Mechanical and Materials Engineering, University of Nebraska, Lincoln, NE, 68588, USA.ORCID 0000-0003-1801-2889
University of Nebraska–Lincoln · USBrigham and Women's Hospital · USPennsylvania State University · USUniversity of Connecticut · US

Funding

Suturable bioprinted vascularized muscle constructs for treatment of skeletal muscle lossR01AR077132 · NIAMS · BRIGHAM AND WOMEN'S HOSPITAL · PI SHIN, SU RYON, TAMAYOL, ALI · 2021 to 2025
$2.6M
Microengineered scaffolds carrying patient-specific cells and growth factors for treatment of volumetric muscle lossR01AR073822 · NIAMS · UNIVERSITY OF NEBRASKA LINCOLN · PI TAMAYOL, ALI · 2018 to 2022
$1.8M
Multifunctional dressing for treatment of diabetic woundsR01GM126831 · NIGMS · UNIVERSITY OF NEBRASKA LINCOLN · PI DOKMECI, MEHMET REMZI, TAMAYOL, ALI · 2018 to 2021
$1.3M
NIAMS NIH HHS R01 AR073822NIAMS NIH HHS R01 AR077132NIGMS NIH HHS R01 GM126831
6 · The paper itself

Abstract

Extremity skeletal muscle injuries result in substantial disability. Current treatments fail to recoup muscle function, but properly designed and implemented tissue engineering and regenerative medicine techniques can overcome this challenge. In this study, a nanoengineered, growth factor-eluting bioink that utilizes Laponite nanoclay for the controlled release of vascular endothelial growth factor (VEGF) and a GelMA hydrogel for a supportive and adhesive scaffold that can be crosslinked in vivo is presented. The bioink is delivered with a partially automated handheld printer for the in vivo formation of an adhesive and 3D scaffold. The effect of the controlled delivery of VEGF alone or paired with adhesive, supportive, and fibrilar architecture has not been studied in volumetric muscle loss (VML) injuries. Upon direct in vivo printing, the constructs are adherent to skeletal muscle and sustained release of VEGF. The in vivo printing of muscle ink in a murine model of VML injury promotes functional muscle recovery, reduced fibrosis, and increased anabolic response compared to untreated mice. The in vivo construction of a therapeutic-eluting 3D scaffold paves the way for the immediate treatment of a variety of soft tissue traumas.

Indexed as

Printing, Three-DimensionalTissue EngineeringTissue ScaffoldsAnimalsMiceMuscle, SkeletalVascular Endothelial Growth Factor AWounds and InjuriesVascular Endothelial Growth Factor Afunctional recoveryhandheld printershydrogel scaffoldsin vivo printingsoft tissue injuriesvolumetric muscle loss

Identifiers

PMID33644996
PMCPMC8137605
OpenAlexW3135562911

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.