Evidence map›Paper›PMID 33644823›Full record

ArticleInvestigational new drugs2021

Discovery of an orally active antitumor agent that induces apoptosis and suppresses EMT through heat shock protein 90 inhibition.

Yuqiang Hu, Ming Hao, Chang Zhong, Jun An, Yongsheng Zhang, Zuobin Zhu, Bing Liu, Liangjun Cheng

Abstract read
PubMed Publisher
In one paragraph

Article in Investigational new drugs, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 48% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

Yuqiang HuDepartment of Otolaryngology-Head and Neck Surgery, XuZhou Central Hospital, Xuzhou Clinical School of Xuzhou Medical University, Xuzhou, 221009, China.
Ming HaoDepartment of Otolaryngology-Head and Neck Surgery, The Fourth Affiliated Hospital of Nanjing Medical University, Nanjing, 320111, China.
Chang ZhongDepartment of Otolaryngology-Head and Neck Surgery, XuZhou Central Hospital, Xuzhou Clinical School of Xuzhou Medical University, Xuzhou, 221009, China.
Jun AnDepartment of Otolaryngology-Head and Neck Surgery, XuZhou Central Hospital, Xuzhou Clinical School of Xuzhou Medical University, Xuzhou, 221009, China.
Yongsheng ZhangDepartment of Otolaryngology-Head and Neck Surgery, Xinyi People's Hospital, Xinyi, 221400, China.
Zuobin ZhuSchool of Life Science, Xuzhou Medical University, Xuzhou, 221004, China.
Bing LiuDepartment of Otolaryngology-Head and Neck Surgery, XuZhou Central Hospital, Xuzhou Clinical School of Xuzhou Medical University, Xuzhou, 221009, China. justdoi0086@yeah.net.
Liangjun ChengDepartment of Otolaryngology-Head and Neck Surgery, XuZhou Central Hospital, Xuzhou Clinical School of Xuzhou Medical University, Xuzhou, 221009, China. chengliangjun1968@163.com.
Xuzhou Central Hospital · CNXuzhou Medical College · CNSecond Affiliated Hospital of Nanjing Medical University · CNXintai People's Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background Nowadays, lung cancer seriously affects human health in the world. Therefore, it is of great significance to develop effective anti-lung cancer drugs. Methods In this work, chalcone derivative HYQ97 was designed via a molecular hybridization strategy. It was synthesized by the cycloaddition in the presence of sodium ascorbate under mild conditions. Lung cancer cell lines were cultured to investigate its antitumor effects in vitro and in vivo. Results HYQ97 inhibited the proliferation of lung cancer cell lines. Specifically, its IC

Indexed as

A549 CellsAdministration, OralAnimalsAntineoplastic AgentsApoptosisCell Line, TumorCell ProliferationChalconesDose-Response Relationship, DrugEpithelial-Mesenchymal TransitionHSP90 Heat-Shock ProteinsHumansInhibitory Concentration 50Lung NeoplasmsMiceMice, Inbred BALB CAntineoplastic AgentsChalconesHSP90 Heat-Shock ProteinsApoptosisChalconeEpithelial mesenchymal transitionHsp90In vivoProliferation

Identifiers

PMID33644823
OpenAlexW3133759765

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.