ReviewSleep advances : a journal of the Sleep Research Society2020
The evolving view of replay and its functions in wake and sleep.
Review in Sleep advances : a journal of the Sleep Research Society, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed.
- A sleep schedule incorporating naps benefits the transformation of hierarchical knowledge.Sleep · 2022Trial
- Human hippocampal ripples tune cortical responses based on predicted uncertainty.Nature neuroscience · 2026Article
- A Parallelized, Automated System for Higher-Throughput Spatial Navigation Testing of Rats.eNeuro · 2026Article
- Article
- A hippocampal 'sharp-wave sleep' state that is dissociable from cortical sleep.Nature neuroscience · 2026Article
- A Parallelized, Automated System for Higher-Throughput Spatial Navigation Testing of Rats.bioRxiv : the preprint server for biology · 2025Article
- Sleep and experience-dependent visual plasticity in the adult cerebral cortex: an update.Sleep · 2025Article
- Movie-watching evokes ripple-like activity within events and at event boundaries.Nature communications · 2025Article
- Parallel processing of past and future memories through reactivation and synaptic plasticity mechanisms during sleep.Nature communications · 2025Article
- Sleep is necessary for experience-dependent sequence plasticity in mouse primary visual cortex.Sleep · 2025Article
- Multi-region processing during sleep for memory and cognition.Proceedings of the Japan Academy. Series B, Physical and biological sciences · 2025Review
- Article
- Mystery of the memory engram: History, current knowledge, and unanswered questions.Neuroscience and biobehavioral reviews · 2024Review
- Sleep-related benefits to transitive inference are modulated by encoding strength and joint rank.Learning & memory (Cold Spring Harbor, N.Y.) · 2023Article
- The human brain reactivates context-specific past information at event boundaries of naturalistic experiences.Nature neuroscience · 2023Article
- How our understanding of memory replay evolves.Journal of neurophysiology · 2023Review
- Control of circadian rhythm on cortical excitability and synaptic plasticity.Frontiers in neural circuits · 2023Review
- Imagination as a fundamental function of the hippocampus.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2022Review
- Multiple traces and altered signal-to-noise in systems consolidation: Evidence from the 7T fMRI Natural Scenes Dataset.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Freezing revisited: coordinated autonomic and central optimization of threat coping.Nature reviews. Neuroscience · 2022Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
The term hippocampal replay originally referred to the temporally compressed reinstantiation, during rest, of sequential neural activity observed during prior active wake. Since its description in the 1990s, hippocampal replay has often been viewed as the key mechanism by which a memory trace is repeatedly rehearsed at high speeds during sleep and gradually transferred to neocortical circuits. However, the methods used to measure the occurrence of replay remain debated, and it is now clear that the underlying neural events are considerably more complicated than the traditional narratives had suggested. "Replay-like" activity happens during wake, can play out in reverse order, may represent trajectories never taken by the animal, and may have additional functions beyond memory consolidation, from learning values and solving the problem of credit assignment to decision-making and planning. Still, we know little about the role of replay in cognition, and to what extent it differs between wake and sleep. This may soon change, however, because decades-long efforts to explain replay in terms of reinforcement learning (RL) have started to yield testable predictions and possible explanations for a diverse set of observations. Here, we (1) survey the diverse features of replay, focusing especially on the latest findings; (2) discuss recent attempts at unifying disparate experimental results and putatively different cognitive functions under the banner of RL; (3) discuss methodological issues and theoretical biases that impede progress or may warrant a partial revaluation of the current literature, and finally; (4) highlight areas of considerable uncertainty and promising avenues of inquiry.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.