Evidence map›Paper›PMID 33644725›Full record

ArticleJHEP reports : innovation in hepatology2021

Assessing the impact of COVID-19 on liver cancer management (CERO-19).

Sergio Muñoz-Martínez, Victor Sapena, Alejandro Forner, Jean-Charles Nault, Gonzalo Sapisochin, Lorenza Rimassa, Bruno Sangro, Jordi Bruix, Marco Sanduzzi-Zamparelli, Wacław Hołówko and 75 more

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PubMed Full text at PMC Publisher
In one paragraph

Article in JHEP reports : innovation in hepatology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
40citing papers in PubMed, 1 pooled it
4.8field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

40 citing papers in PubMed, 1 synthesis or guideline pooled it, 65 citations in OpenAlex.

  1. Pooled it
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  9. County-Level Food Insecurity and Hepatocellular Carcinoma Risk: A Cross-Sectional Analysis.International journal of environmental research and public health · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

85 authors at 20 institutions in 20 countries.

Sergio Muñoz-MartínezBCLC group, Liver Unit, Hospital Clinic Barcelona, IDIBAPS, CIBERehd, University of Barcelona, Barcelona, Spain.
Victor SapenaBCLC group, Liver Unit, Hospital Clinic Barcelona, IDIBAPS, CIBERehd, University of Barcelona, Barcelona, Spain.
Alejandro FornerBCLC group, Liver Unit, Hospital Clinic Barcelona, IDIBAPS, CIBERehd, University of Barcelona, Barcelona, Spain.
Jean-Charles NaultService d'hépatologie, Hôpital Avicenne, Hôpitaux Universitaires Paris-Seine-Saint-Denis, Assistance-Publique Hôpitaux de Paris, Bobigny, France.
Gonzalo SapisochinAbdominal Transplant & HPB Surgical Oncology, University Health Network, Toronto General Hospital, University of Toronto, Toronto, Canada.
Lorenza RimassaMedical Oncology and Hematology Unit, Humanitas Cancer Center, Humanitas Clinical and Research Center - IRCCS, Rozzano, Milan, Italy.
Bruno SangroUnidad de Hepatología, Clínica Universidad de Navarra, IDISNA, CIBERehd, Pamplona, Spain.
Jordi BruixBCLC group, Liver Unit, Hospital Clinic Barcelona, IDIBAPS, CIBERehd, University of Barcelona, Barcelona, Spain.
Marco Sanduzzi-ZamparelliBCLC group, Liver Unit, Hospital Clinic Barcelona, IDIBAPS, CIBERehd, University of Barcelona, Barcelona, Spain.
Wacław HołówkoDepartment of General, Transplant and Liver Surgery, Medical University of Warsaw, Warsaw, Poland.
Mohamed El KassasEndemic Medicine Department, Faculty of Medicine, Helwan University, Cairo, Egypt.
Tudor Mocan3rd Medical Department, 'Octavian Fodor' Institute for Gastroenterology and Hepatology, Cluj-Napoca, Romania.
Mohamed BouattourAP-HP, Hôpital Beaujon, Department of Digestive Oncology, Clichy, France.
Philippe MerleDepartment of Hepatology, Groupement Hospitalier Lyon Nord, Lyon, France.
Frederik J H HoogwaterDepartment of Hepato-Pancreato-Biliary Surgery and Liver Transplantation, University Medical Center Groningen, Groningen, the Netherlands.
Saleh A AlqahtaniDepartment of Liver Transplant, King Faisal Specialist Hospital & Research Center, Riyadh, Saudi Arabia.
Helen L ReevesLiver Unit, Newcastle Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK.
David J PinatoDepartment of Surgery and Cancer, Imperial College London, London, UK.
Emmanouil GiorgakisDivision of Transplantation, Department of Surgery, UAMS Medical Center, Winthrop P. Rockefeller Cancer Institute, Little Rock, AK, USA.
Tim MeyerDepartment of Oncology, Royal Free Hospital, London, UK.
Gerda Elisabeth VilladsenDepartment of Hepatology and Gastroenterology, Aarhus University Hospital, Aarhus, Denmark.
Henning WegeDepartment of Internal Medicine, Gastroenterology and Hepatology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Massimiliano SalatiDepartment of Clinical and Experimental Medicine, University Hospital of Modena and Reggio Emilia, Modena, Emilia-Romagna, Italy.
Beatriz MínguezLiver Unit, Hospital Universitari Vall d'Hebron, Liver Diseases Research Group, Vall d'Hebron Institut of Research (VHIR), Vall d'Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona, Barcelona, Spain.
Giovan Giuseppe Di CostanzoLiver Unit, A Cardarelli Hospital, Naples, Italy.
Christoph RoderburgDepartment of Hepatology and Gastroenterology, Charité University Medicine Berlin, Berlin, Germany.
Frank TackeDepartment of Hepatology and Gastroenterology, Charité University Medicine Berlin, Berlin, Germany.
María VarelaDepartment of Gastroenterology and Hepatology. Hospital Universitario Central de Asturias, IUOPA, ISPA, Universidad de Oviedo, Oviedo, Spain.
Peter R GalleI. Department of Internal Medicine, University Medical Center Mainz, Mainz, Germany.
Mario Reis Alvares-da-SilvaGI/Liver Unit, Hospital de Clínicas de Porto Alegre, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil.
Jörg TrojanMedical Clinic 1, Goethe University Hospital, Frankfurt, Germany.
John BridgewaterDepartment of Oncology, University College of London, London, UK.
Giuseppe CabibboSection of Gastroenterology and Hepatology, PROMISE, University of Palermo, Palermo, Italy.
Christian TosoDepartment of Surgery, Geneva University Hospitals, Geneva, Switzerland.
Anja LachenmayerDepartment of Visceral Surgery and Medicine, Inselspital, Bern University Hospital, Bern, Switzerland.
Andrea Casadei-GardiniDepartment of Medical Oncology, University of Modena and Reggio Emilia, Modena, Italy.
Hidenori ToyodaDepartment of Gastroenterology, Ogaki Municipal Hospital, Ogaki, Japan.
Tom LüddeClinic for Gastroenterology, Hepatology and Infectious Disease, University Hospital Düsseldorf, Düsseldorf, Germany.
Rosanna VillaniLiver Unit, Department of Surgical and Medical Sciences, University of Foggia, Foggia, Italy.
Ana María Matilla PeñaGastroenterology and Hepatology, H.G.U. Gregorio Marañon, CIBERehd, Madrid, Spain.
Cassia Regina Guedes LealGastroenterology, Hospital Federal dos Servidores do Estado, Rio de Janeiro, Brazil.
Monica RonzoniMedical Oncology Unit, IRCCS Ospedale San Raffaele, Milan, Italy.
Manuel DelgadoDepartment of Digestive Disease, University Hospital La Coruña, La Coruña, Spain.
Christie PerellóDepartment of Gastroenterology and Hepatology, University Hospital Puerta de Hierro, Majadahonda, Spain.
Sonia PascualLiver Unit, HGU Alicante, CIBERehd, Alicante, Spain.
José Luis LledóDepartment of Gastroenterology and Hepatology, Hospital Universitario Ramón y Cajal, Madrid, Spain.
Josepmaria ArgemiInternal Medicine - Liver Unit, Clinica Universidad de Navarra, Pamplona, Spain.
Bristi BasuDepartment of Oncology, University of Cambridge, Cambridge, UK.
Leonardo da FonsecaDepartment of Clinical Oncology, Sao Paulo Clinicas Liver Cancer group, Insitituto do Cancer do Estado de São Paulo, University of São Paulo, San Paulo, Brazil.
Juan AcevedoSouth West Liver Unit, University Hospitals Plymouth NHS Trust, Plymouth, UK.
Alexander R SiebenhünerDepartment of Medical Oncology and Hematology, University Hospital Zurich, University of Zurich, Zurich, Switzerland.
Chiara BraconiDepartment of Medical Oncology, Beatson West of Scotland Cancer Centre, University of Glasgow, Glasgow, UK.
Brandon M MeyersDepartment of Oncology, Juravinski Cancer Centre, McMaster University, Hamilton, ON, Canada.
Alessandro GranitoDivision of Internal Medicine, Azienda Ospedaliero-Universitaria di Bologna, Department of Medical and Surgical Sciences, University of Bologna, Bologna, Italy.
Margarita SalaDepartment of Gastroenterology, Hepatology Unit, Hospital Doctor Josep Trueta, CIBERehd, Girona, Spain.
Carlos Rodríguez-LopeServicio de Aparato Digestivo, Hospital Universitario Marqués de Valdecilla, IDIVAL, Santander, Spain.
Lorraine BlaiseService d'hépatologie, Hôpital Avicenne, Hôpitaux Universitaires Paris-Seine-Saint-Denis, Assistance-Publique Hôpitaux de Paris, Bobigny, France.
Manuel Romero-GómezSeLiver group, UGC de Enfermedades Digestivas, Instituto de Biomedicina de Sevilla, Hospital Virgen del Rocío, CIBERehd, Seville, Spain.
Federico PiñeroLiver Unit, Hospital Universitario Austral, Pilar, Argentina.
Dhanny GomezHPB Surgery and Hepatology, Nottingham University Hospitals NHS Trust, Nottingham, UK.
Vivianne MelloDepartment of Oncology, AMO Clinic, Salvador, Brazil.
Rogerio Camargo Pinheiro AlvesDepartment of Gastroenterology, Hospital do Servidor Publico Estadual de São Paulo, San Paulo, Brazil.
Alex FrançaDepartment of Medicine, Federal University of Sergipe, Aracaju, Brazil.
Fernanda BrancoDepartment of Hepatology, CliniOnco, Porto Alegre, Brazil.
Giovanni BrandiDivision of Oncology - Department of Experimental, Diagnostic and Specialty Medicine, S. Orsola-Malpighi Hospital, Bologna, Italy.
Gustavo PereiraGastroenterology and Hepatology Unit, Hospital Federal de Bonsucesso, Rio de Janeiro, Brazil.
Susanna CollHepatology Section, Gastroenterology Department, Hospital del Mar, IMIM (Hospital del Mar Medical Research Institute), Barcelona, Spain.
Maria GuarinoDepartment of Clinical Medicine and Surgery, University of Naples Federico II, Naples, Italy.
Carlos BenítezDepartment of Gastroenterology, Pontificia Universidad Católica de Chile, Santiago, Chile.
Maria Margarita AndersSección Hepatología, Hospital Aleman, Buenos Aires, Argentina.
Juan C BandiDepartment of Hepatology, Hospital Italiano, Buenos Aires, Argentina.
Mercedes VergaraUnitat d'Hepatologia, Servei d'Aparell Digestiu, Parc Taulí Sabadell Hospital Universitari, Institut d'Investigació i Innovació I3PT, Universitat Autònoma de Barcelona, Sabadell, Barcelona, Spain.
Mariona CalvoOncología Médica, Institut Català d'Oncologia, L'Hospitalet del Llobregat, Barcelona, Spain.
Markus Peck-RadosavljevicInnere Medizin & Gastroenterologie, Klinikum Klagenfurt am Wörthersee, Klagenfurt am Wörthersee, Austria.
Ignacio García-JuárezGastroenterology Department, National Institute of Medical Sciences and Nutrition Salvador Zubirán, Mexico City, Mexico.
Vincenzo CardinaleDepartment of Medico-Surgical Sciences and Biotechnologies, Sapienza University of Rome, Polo Pontino, Italy.
Mar LozanoAparato Digestivo, Hospital Universitario Infanta Leonor, Madrid, Spain.
Martina GambatoDepartment of Surgery, Oncology and Gastroenterology, Padua University Hospital, Padua, Italy.
Stefano OkolicsanyiDepartment of Surgical Disciplines, Gastroenterology and Digestive Endoscopy, Umberto Parini Hospital, Aosta, Italy.
Dalia Morales-ArraezDepartment of Gastroenterology and Hepatology, Hospital Universitario de Canarias, La Laguna, Spain.
Alessandra ElveviDivision of Gastroenterology and Center for Autoimmune Liver Diseases, San Gerardo Hospital University of Milano-Bicocca School of Medicine, Monza, Italy.
Alberto E MuñozSección Hepatología, Hospital Dr. Carlos Bonorino Udaondo, Buenos Aires, Argentina.
Alberto LuéGastroenterology, Hepatology and Nutrition Unit, San Jorge General Hospital, Huesca, Spain.
Massimo IavaroneFoundation IRCCS Ca' Granada Ospedale Maggiore Policlinico, Division of Gastroenterology and Hepatology, CRC 'A.M. and A. Migliavacca' Center for Liver Disease, Milan, Italy.
Maria ReigBCLC group, Liver Unit, Hospital Clinic Barcelona, IDIBAPS, CIBERehd, University of Barcelona, Barcelona, Spain.
Hospital Clínic de Barcelona · ESCentro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas · ESCharité - Universitätsmedizin Berlin · DEInserm · FRUniversitat Autònoma de Barcelona · ESUniversity of Modena and Reggio Emilia · ITAarhus University Hospital · DKAzienda USL di Bologna · ITBeatson West of Scotland Cancer Centre · GBClinica Universidad de Navarra · ESDüsseldorf University Hospital · DEFondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico · ITGoethe University Frankfurt · DEHelwan University · EGHôpital Beaujon · FRHôpital Lyon Sud · FRHospital Alemán · ARHospital Del Mar · ESHospital do Servidor Público Estadual · BRHospital Federal dos Servidores do Estado · BR

Funding

Cancer Research UK 26813Wellcome Trust
6 · The paper itself

Abstract

BACKGROUND &

aimsThe coronavirus disease 2019 (COVID-19) pandemic has posed unprecedented challenges to healthcare systems and it may have heavily impacted patients with liver cancer (LC). Herein, we evaluated whether the schedule of LC screening or procedures has been interrupted or delayed because of the COVID-19 pandemic.

methodsAn international survey evaluated the impact of the COVID-19 pandemic on clinical practice and clinical trials from March 2020 to June 2020, as the first phase of a multicentre, international, and observational project. The focus was on patients with hepatocellular carcinoma or intrahepatic cholangiocarcinoma, cared for around the world during the first COVID-19 pandemic wave.

resultsNinety-one centres expressed interest to participate and 76 were included in the analysis, from Europe, South America, North America, Asia, and Africa (73.7%, 17.1%, 5.3%, 2.6%, and 1.3% per continent, respectively). Eighty-seven percent of the centres modified their clinical practice: 40.8% the diagnostic procedures, 80.9% the screening programme, 50% cancelled curative and/or palliative treatments for LC, and 41.7% modified the liver transplantation programme. Forty-five out of 69 (65.2%) centres in which clinical trials were running modified their treatments in that setting, but 58.1% were able to recruit new patients. The phone call service was modified in 51.4% of centres which had this service before the COVID-19 pandemic (n = 19/37).

conclusionsThe first wave of the COVID-19 pandemic had a tremendous impact on the routine care of patients with liver cancer. Modifications in screening, diagnostic, and treatment algorithms may have significantly impaired the outcome of patients. Ongoing data collection and future analyses will report the benefits and disadvantages of the strategies implemented, aiding future decision-making. LAY SUMMARY: The coronavirus disease 2019 (COVID-19) pandemic has posed unprecedented challenges to healthcare systems globally. Herein, we assessed the impact of the first wave pandemic on patients with liver cancer and found that routine care for these patients has been majorly disrupted, which could have a significant impact on outcomes.

Indexed as

BCLC, Barcelona Clinic Liver CancerCERO-19, Liver Cancer Outcome in the COVID-19-pandemic ProjectCholangiocarcinomaClinical trialsCOVID-19COVID-19, coronavirus disease 2019ENS-CCA, European Network for the Study of CholangiocarcinomaHCC, hepatocellular carcinomaHepatocellular carcinomaiCCA, intrahepatic cholangiocarcinomaLC, liver cancerLiver cancerLT, liver transplantationManagementNursesSARS-CoV-2, severe acute respiratory syndrome coronavirus-2

Identifiers

PMID33644725
PMCPMC7901294
OpenAlexW3130529097

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.