ArticleACS applied bio materials2020
Analysis of vascular inflammation against bioresorbable Zn-Ag based alloys.
Article in ACS applied bio materials, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
19 citing papers in PubMed, 44 citations in OpenAlex.
- Strut Thickness and Species-Specific Healing Are Key Considerations in Developing Zinc-Based Biodegradable Arterial Stents.Journal of biomedical materials research. Part B, Applied biomaterials · 2026Article
- Mg-Y-Nd alloy biocorrosion behavior in hyperlipidemia models in vitro and in vivo.Acta biomaterialia · 2026Article
- Microstructural Control of Zn Alloy by Melt Spinning - A Novel Approach Towards Fabrication of Advanced Biodegradable Biomedical Materials.Materials science & engineering. A, Structural materials : properties, microstructure and processing · 2025Article
- The biological effects of copper alloying in Zn-based biodegradable arterial implants.Biomaterials advances · 2025Article
- MicroCT and contrast-enhanced microCT to study the in vivo degradation behavior and biocompatibility of candidate metallic intravascular stent materials.Acta biomaterialia · 2025Article
- Progress in research and development of biodegradable metallic vascular stents.Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2024Review
- Thrombogenicity of biodegradable metals.Bioactive materials · 2024Article
- The influence of age on the biological response to biodegradable zinc arterial implants.Materialia · 2024Article
- Mechanical Properties and Corrosion Rate of ZnAg3 as a Novel Bioabsorbable Material for Osteosynthesis.Journal of functional biomaterials · 2024Article
- Insights into the biocompatibility of biodegradable metallic molybdenum for cardiovascular applications-a critical review.Frontiers in bioengineering and biotechnology · 2024Review
- Absorbable metal stents for vascular use in pediatric cardiology: progress and outlook.Frontiers in cardiovascular medicine · 2024Review
- Biocompatibility Assessment of Zinc Alloys as a New Potential Material for Bioabsorbable Implants for Osteosynthesis.Materials (Basel, Switzerland) · 2023Article
- A Comprehensive Review of the Current Research Status of Biodegradable Zinc Alloys and Composites for Biomedical Applications.Materials (Basel, Switzerland) · 2023Review
- Immune response differences in degradable and non-degradable alloy implants.Bioactive materials · 2023Review
- Additive manufacturing of sustainable biomaterials for biomedical applications.Asian journal of pharmaceutical sciences · 2023Review
- Shape Memory Polymer Composites: 4D Printing, Smart Structures, and Applications.Research (Washington, D.C.) · 2023Review
- Bioresorbable vascular metallic scaffolds: Current status and research trends.Current opinion in biomedical engineering · 2022Article
- In-vivo evaluation of molybdenum as bioabsorbable stent candidate.Bioactive materials · 2022Article
- Improved biocompatibility of Zn-Ag-based stent materials by microstructure refinement.Acta biomaterialia · 2022Article
Corrections and comments
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
Abstract
Zinc (Zn) has emerged as a promising bioresorbable stent material due to its satisfactory corrosion behavior and excellent biocompatibility. However, for load bearing implant applications, alloying is required to boost its mechanical properties as pure Zn exhibits poor strength. Unfortunately, an increase in inflammation relative to pure Zn is a commonly observed side-effect of Zn alloys. Consequently, the development of a Zn-based alloy that can simultaneously feature improved mechanical properties and suppress inflammatory responses is a big challenge. Here, a bioresorbable, biocompatible Zn-Ag-based quinary alloy was comprehensively evaluated in vivo, in comparison to reference materials. The inflammatory and smooth muscle cellular response was characterized and correlated to metrics of neointimal growth. We found that implantation of the quinary alloy was associated with significantly improved inflammatory activities relative to the reference materials. Additionally, we found that inflammation, but not smooth muscle cell hyperplasia, significantly correlates to neointimal growth for Zn alloys. The results suggest that inflammation is the main driver of neointimal growth for Zn-based alloys and that the quinary Zn-Ag-Mn-Zr-Cu alloy may impart inflammation-resistance properties to arterial implants.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.