Evidence map›Paper›PMID 33644628›Full record

ReviewAPL bioengineering2021

Application of machine learning in understanding atherosclerosis: Emerging insights.

Eric Munger, John W Hickey, Amit K Dey, Mohsin Saleet Jafri, Jason M Kinser, Nehal N Mehta

Abstract readReview
In one paragraph

Review in APL bioengineering, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Interpretable machine learning analysis for relationships betweenFrontiers in cellular and infection microbiology · 2026
    Article
  2. Article
  3. Review
  4. A machine learning model for non-invasive detection of atherosclerotic coronary artery aneurysm.International journal of computer assisted radiology and surgery · 2022
    Article
  5. Article
  6. Review
  7. Review
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

John W HickeyStanford University, Stanford, California 94306, USA.ORCID https://orcid.org/0000-0001-9961-7673
Amit K DeyNational Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892, USA.ORCID https://orcid.org/0000-0002-7750-910X
Mohsin Saleet JafriGeorge Mason University, Fairfax, Virginia 22030, USA.ORCID https://orcid.org/0000-0003-3174-1007
Jason M KinserGeorge Mason University, Fairfax, Virginia 22030, USA.ORCID https://orcid.org/0000-0003-0078-4899
Nehal N MehtaNational Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892, USA.ORCID https://orcid.org/0000-0003-4939-5130

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Biological processes are incredibly complex-integrating molecular signaling networks involved in multicellular communication and function, thus maintaining homeostasis. Dysfunction of these processes can result in the disruption of homeostasis, leading to the development of several disease processes including atherosclerosis. We have significantly advanced our understanding of bioprocesses in atherosclerosis, and in doing so, we are beginning to appreciate the complexities, intricacies, and heterogeneity atherosclerosi. We are also now better equipped to acquire, store, and process the vast amount of biological data needed to shed light on the biological circuitry involved. Such data can be analyzed within machine learning frameworks to better tease out such complex relationships. Indeed, there has been an increasing number of studies applying machine learning methods for patient risk stratification based on comorbidities, multi-modality image processing, and biomarker discovery pertaining to atherosclerotic plaque formation. Here, we focus on current applications of machine learning to provide insight into atherosclerotic plaque formation and better understand atherosclerotic plaque progression in patients with cardiovascular disease.

Identifiers

PMID33644628
PMCPMC7889295

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.