Evidence map›Paper›PMID 33644453›Full record

ArticleHeliyon2021

Antibacterial coating of tooth surface with ion-releasing pre-reacted glass-ionomer (S-PRG) nanofillers.

Kayoko Mayumi, Hirofumi Miyaji, Saori Miyata, Erika Nishida, Tomokazu Furihata, Yukimi Kanemoto, Tsutomu Sugaya, Kanako Shitomi, Tsukasa Akasaka

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Heliyon, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
2.1field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 18 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Kayoko MayumiDepartment of Periodontology and Endodontology, Faculty of Dental Medicine, Hokkaido University, N13 W7, Kita-ku, Sapporo, Hokkaido, 060-8586, Japan.
Hirofumi MiyajiDepartment of Periodontology and Endodontology, Faculty of Dental Medicine, Hokkaido University, N13 W7, Kita-ku, Sapporo, Hokkaido, 060-8586, Japan.
Saori MiyataDepartment of Periodontology and Endodontology, Faculty of Dental Medicine, Hokkaido University, N13 W7, Kita-ku, Sapporo, Hokkaido, 060-8586, Japan.
Erika NishidaDepartment of Periodontology and Endodontology, Faculty of Dental Medicine, Hokkaido University, N13 W7, Kita-ku, Sapporo, Hokkaido, 060-8586, Japan.
Tomokazu FurihataDepartment of Periodontology and Endodontology, Faculty of Dental Medicine, Hokkaido University, N13 W7, Kita-ku, Sapporo, Hokkaido, 060-8586, Japan.
Yukimi KanemotoDepartment of Periodontology and Endodontology, Faculty of Dental Medicine, Hokkaido University, N13 W7, Kita-ku, Sapporo, Hokkaido, 060-8586, Japan.
Tsutomu SugayaDepartment of Periodontology and Endodontology, Faculty of Dental Medicine, Hokkaido University, N13 W7, Kita-ku, Sapporo, Hokkaido, 060-8586, Japan.
Kanako ShitomiDivision of Periodontology and Endodontology, School of Dentistry, Health Sciences University of Hokkaido, 1757 Kanazawa, Tobetsu-cho, Ishikari-gun, Hokkaido, 061-0293, Japan.
Tsukasa AkasakaDepartment of Biomedical Materials and Engineering, Faculty of Dental Medicine, Hokkaido University, N13 W7, Kita-ku, Sapporo, Hokkaido, 060-8586, Japan.
Hokkaido University · JPHealth Sciences University of Hokkaido · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesSurface pre-reacted glass-ionomer (S-PRG) fillers release antibacterial borate and fluoride ions. We fabricated nanoscale S-PRG fillers (S-PRG nanofillers) for antibacterial coating of tooth surfaces and assessed the antibacterial effects of this coating in vitro. In addition, we creating a canine model of periodontitis to evaluate the effectiveness of S-PRG nanofiller application on tooth roots and improvement of periodontal parameters.

methodsHuman dentin blocks were coated with S-PRG nanofiller (average particle size: 0.48 μm) and then characterized by scanning electron microscopy (SEM), energy dispersive X-ray spectrometer (EDX), and ion-releasing test. Antibacterial effects of dentin blocks coated with S-PRG nanofiller were examined using bacterial strains,

resultsSEM and EDX revealed that S-PRG nanofillers uniformly covered the dentin surface after coating. Dentin blocks coated with S-PRG nanofiller showed ion-releasing property, bacterial growth inhibition, and sterilization effects. In the experimental periodontitis model, S-PRG nanofiller coating significantly reduced clinical inflammatory parameters, such as GI (P < 0.01) and BOP (P < 0.05), compared to uncoated samples. In addition, PPD and CAL significantly decreased by S-PRG nanofiller coating (2 weeks: P < 0.05; 3 and 4 weeks: P < 0.01), suggesting the improvement of periodontitis. Micro-CT and histology revealed that bone healing of furcation defects was enhanced by S-PRG nanofiller coating.

conclusionS-PRG nanofiller coating provides antibacterial effects to tooth surfaces and improves clinical parameters of periodontitis.

Indexed as

Actinomyces naeslundiiAnimal modelAntibacterial activityAnti-inflammatoryClass II furcation defectIon-releasingPeriodontitisRoot dentinStreptococcus mutansSurface pre-reacted glass-ionomer (S-PRG) filler

Identifiers

PMID33644453
PMCPMC7889979
OpenAlexW3128376834

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.