ArticleOne health (Amsterdam, Netherlands)2021
One Health drivers of antibacterial resistance: Quantifying the relative impacts of human, animal and environmental use and transmission.
Article in One health (Amsterdam, Netherlands), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
55 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Animal sources of antimicrobial-resistant bacterial infections in humans: a systematic review.Epidemiology and infection · 2023Pooled it
- Assessment and tracking of antimicrobial resistance in Escherichia coli as a one health perspective.World journal of microbiology & biotechnology · 2026Article
- Mapping the landscape of mathematical models for antimicrobial resistance: a scoping review.BMC public health · 2026Article
- Mapping antimicrobial resistance interventions in ASEAN countries: a scoping review of implementation patterns, One Health integration, and evidence gaps.Tropical medicine and health · 2026Review
- Ecopharmacovigilance and pharmacovigilance: an analysis of environment-related reporting in VigiBase.Environmental science and pollution research international · 2026Article
- A One Health Perspective onMicroorganisms · 2026Review
- Metagenomic Insights into Antimicrobial Resistance in Small-Scale Poultry and Cattle Farms.Microorganisms · 2026Article
- Development of AWaRe-Based Quality Indicators to Assess the Appropriateness of Antibiotic Prescribing in Primary Healthcare in South Africa.Antibiotics (Basel, Switzerland) · 2026Article
- A One Health study ofMicrobial genomics · 2026Article
- Antimicrobial Resistance Profiles of Enterobacteriaceae in Surface Water From Streams and the Southern Gulf of Lake Tana, Ethiopia.Environmental health insights · 2026Article
- A 'One Health' cross-sectional analysis of reports of potential antibiotic resistance cases in international pharmacovigilance databases.Frontiers in public health · 2026Article
- The Impact of the COVID-19 Pandemic on Antimicrobial Resistance Trends in a Tertiary Care Teaching Hospital: A Ten-Year Surveillance Study.Antibiotics (Basel, Switzerland) · 2025Article
- Antimicrobial resistance prevalence inApplied and environmental microbiology · 2025Article
- Antimicrobial Resistance Profiles of Bacteria Isolated from the Animal Health Sector in Zambia (2020-2024): Opportunities to Strengthen Antimicrobial Resistance Surveillance and Stewardship Programs.Antibiotics (Basel, Switzerland) · 2025Article
- Bridging the prevention gap: funding distribution and methodological shifts in prevention-focused biomedical research under EU framework programmes.Journal of translational medicine · 2025Article
- Synthesis of Silver Nanoparticles from Bitter Melon (Microorganisms · 2025Article
- Rapid whole genome sequencing for AMR surveillance in low- and middle-income countries: Oxford Nanopore Technology reveals multidrug-resistant Enterobacter cloacae complex from dairy farms in Sri Lanka.BMC veterinary research · 2025Article
- Differing terminology used to describe antimicrobial resistance can influence comprehension and subsequent behavioural intent.Communications medicine · 2025Article
- Exploring antibiotic stewardship interventions within a One Health context: a scoping review.Frontiers in public health · 2025Article
- Influences on limited antimicrobial use in small-scale freshwater aquaculture farms in central Thailand.Frontiers in veterinary science · 2025Article
Corrections and comments
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Authors and funding
18 authors.
Funding
Abstract
objectivesAntibacterial resistance (ABR) is a major global health security threat, with a disproportionate burden on lower-and middle-income countries (LMICs). It is not understood how 'One Health', where human health is co-dependent on animal health and the environment, might impact the burden of ABR in LMICs. Thailand's 2017 "National Strategic Plan on Antimicrobial Resistance" (NSP-AMR) aims to reduce AMR morbidity by 50% through 20% reductions in human and 30% in animal antibacterial use (ABU). There is a need to understand the implications of such a plan within a One Health perspective.
methodsA model of ABU, gut colonisation with extended-spectrum beta-lactamase (ESBL)-producing bacteria and transmission was calibrated using estimates of the prevalence of ESBL-producing bacteria in Thailand. This model was used to project the reduction in human ABR over 20 years (2020-2040) for each One Health driver, including individual transmission rates between humans, animals and the environment, and to estimate the long-term impact of the NSP-AMR intervention.
resultsThe model predicts that human ABU was the most important factor in reducing the colonisation of humans with resistant bacteria (maximum 65.7-99.7% reduction). The NSP-AMR is projected to reduce human colonisation by 6.0-18.8%, with more ambitious targets (30% reductions in human ABU) increasing this to 8.5-24.9%.
conclusionsOur model provides a simple framework to explain the mechanisms underpinning ABR, suggesting that future interventions targeting the simultaneous reduction of transmission and ABU would help to control ABR more effectively in Thailand.
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