Evidence map›Paper›PMID 33644235›Full record

Trial reportJournal of immunology research2021

Seroconversion and Abundance of IgG Antibodies against S1-RBD of SARS-CoV-2 and Neutralizing Activity in the Chilean Population.

R González-Stegmaier, K Cereceda, J L Briones, C Beltran-Pávez, A Oyarzún-Arrau, S Riquelme-Barrios, C Selman, F Yarad, M Mahave, C Caglevic and 7 more

Registry-linked trialOpen access · goldAbstract readClinical Trial
In one paragraph

Trial report in Journal of immunology research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04384588 (Investigational- Compassionate Use of Convalescent Plasma From COVID-19 Donors in Oncological and Non-Oncological Patients With Severity Criteria), which is not on this map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.4field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04384588 phase2 / phase3unknown statusnot on this map

Investigational- Compassionate Use of Convalescent Plasma From COVID-19 Donors in Oncological and Non-Oncological Patients With Severity Criteria: FALP 001-2020 Trial (FALP-COVID)

TypeinterventionalSponsorFundacion Arturo Lopez PerezRan2020 to 2021Enrolled100ConditionsCOVID-19 Infection, Cancer Patients, General PopulationArmsConvalescent Plasma from COVID-19 donors
3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 2 institutions in 1 country.

R González-StegmaierTranslational Medicine Laboratory, Instituto Oncológico Fundación Arturo López Pérez, Santiago, Chile.
K CerecedaTranslational Medicine Laboratory, Instituto Oncológico Fundación Arturo López Pérez, Santiago, Chile.
J L BrionesHaematology Department, Instituto Oncológico Fundación Arturo López Pérez, Santiago, Chile.
C Beltran-PávezLaboratory of Molecular and Cellular Virology, Virology Program, Institute of Biomedical Sciences, Faculty of Medicine, Universidad de Chile, Chile.
A Oyarzún-ArrauLaboratory of Molecular and Cellular Virology, Virology Program, Institute of Biomedical Sciences, Faculty of Medicine, Universidad de Chile, Chile.
S Riquelme-BarriosLaboratory of Molecular and Cellular Virology, Virology Program, Institute of Biomedical Sciences, Faculty of Medicine, Universidad de Chile, Chile.
C SelmanDiagnostic Units, Instituto Oncológico Fundación Arturo López Pérez, Santiago, Chile.
F YaradDiagnostic Units, Instituto Oncológico Fundación Arturo López Pérez, Santiago, Chile.
M MahaveMedical Oncology Department, Instituto Oncológico Fundación Arturo López Pérez, Santiago, Chile.
C CaglevicCancer Research Department, Instituto Oncológico Fundación Arturo López Pérez, Santiago, Chile.
R MoralesInternal Medicine Department, Instituto Oncológico Fundación Arturo López Pérez, Santiago, Chile.
A AguirreTranslational Medicine Laboratory, Instituto Oncológico Fundación Arturo López Pérez, Santiago, Chile.
F Valiente-EcheverríaLaboratory of Molecular and Cellular Virology, Virology Program, Institute of Biomedical Sciences, Faculty of Medicine, Universidad de Chile, Chile.
R Soto-RifoLaboratory of Molecular and Cellular Virology, Virology Program, Institute of Biomedical Sciences, Faculty of Medicine, Universidad de Chile, Chile.
H MarsigliaRadiotherapy Department, Instituto Oncológico Fundación Arturo López Pérez, Santiago, Chile.
R GazituaHaematology Department, Instituto Oncológico Fundación Arturo López Pérez, Santiago, Chile.ORCID https://orcid.org/0000-0002-1269-7322
F Villarroel-EspindolaTranslational Medicine Laboratory, Instituto Oncológico Fundación Arturo López Pérez, Santiago, Chile.ORCID https://orcid.org/0000-0003-0080-2444
Fundación Arturo López Pérez · CLUniversity of Chile · CL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

COVID-19 is a pandemic caused by SARS-CoV-2. In Chile, half a million people have been infected and more than 16,000 have died from COVID-19. As part of the clinical trial NCT04384588, we quantified IgG against S1-RBD of SARS-CoV-2 (anti-RBD) in recovered people in Santiago and evaluated their suitability as COVID-19 convalescent plasma donors. ELISA and a luminescent SARS-CoV-2 pseudotype were used for IgG and neutralizing antibody quantification. 72.9% of the convalescent population (468 of 639) showed seroconversion (5-55

Indexed as

AdolescentAdultAntibodies, NeutralizingAntibodies, ViralChileCOVID-19COVID-19 SerotherapyFemaleHumansImmunization, PassiveImmunoglobulin GMaleMiddle AgedPandemicsSARS-CoV-2SeroconversionAntibodies, NeutralizingAntibodies, ViralImmunoglobulin GSpike Glycoprotein, Coronavirus

Identifiers

PMID33644235
PMCPMC7901042
OpenAlexW3131337472

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.