ArticleWorld journal of clinical cases2021
New indicators in evaluation of hemolysis, elevated liver enzymes, and low platelet syndrome: A case-control study.
Article in World journal of clinical cases, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed, 10 citations in OpenAlex.
- Evaluation of albumin-based inflammatory markers as diagnostic tools in HELLP syndrome.Scientific reports · 2025Article
- The association of manganese levels with red cell distribution width: A population-based study.PloS one · 2024Article
- Distinct cytokine profiles in patients with preeclampsia.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2023Article
- [Clinical Comparative Analysis of Early-Onset Preeclampsia Combined with HELLP Syndrome].Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition · 2022Article
- Clinical Classification, Pregnancy Outcomes and Risk Factors Analysis of Severe Preeclampsia Complicated With HELLP Syndrome.Frontiers in surgery · 2022Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIndices such as the neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), mean platelet volume (MPV), platelet distribution width (PDW), and red cell distribution width (RDW) are considered new markers of the systemic inflammatory response (SIR), and have been widely implemented for the diagnosis of patients with inflammatory diseases. These new indicators have also been widely investigated in preeclampsia (PE) but less analyzed in hemolysis, elevated liver enzymes, and low platelet (HELLP) syndrome.
aimTo compare SIR markers among HELLP patients, PE only patients, and healthy gravidae.
methodsThis retrospective case-control study enrolled 630 cases, including 210 patients with HELLP syndrome (HELLP group), 210 patients with only PE (PE group) and 210 healthy gravidae (control group). The three groups were matched by age, parity, status of assisted reproduction, and multiple pregnancies. Birthweight, gestational age at complete blood count collection, gestational age at delivery, mode of delivery,
resultsThe NLR (6.4
conclusionSIR markers such as NLR, RDW, MPV, and PDW were increased and PLR was decreased in HELLP. These SIR markers may become new indicators in the evaluation of HELLP syndrome.
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Registered trials
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