Evidence map›Paper›PMID 33644069›Full record

ArticleFrontiers in cell and developmental biology2021

Flavin-Containing Monooxygenases Are Conserved Regulators of Stress Resistance and Metabolism.

Shijiao Huang, Marshall B Howington, Craig J Dobry, Charles R Evans, Scott F Leiser

Open access · goldAbstract read
In one paragraph

Article in Frontiers in cell and developmental biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed
4.7field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 63 citations in OpenAlex.

  1. Article
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  7. Phenotypic and metabonomics studies of FMOs in C. elegans and their roles in lifespan extension.Metabolomics : Official journal of the Metabolomic Society · 2025
    Article
  8. Article
  9. Unravelling Osteoporosis: Key Genes and Potential Therapies.Journal of cellular and molecular medicine · 2025
    Article
  10. Article
  11. Therapeutic Effects ofInternational journal of molecular sciences · 2025
    Article
  12. eLife · 2025
    Article
  13. Perception ofmicroPublication biology · 2025
    Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Flavin-containing monooxygenase (FMO): Beyond xenobiotics.BioEssays : news and reviews in molecular, cellular and developmental biology · 2024
    Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Shijiao HuangDepartment of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI, United States.
Marshall B HowingtonCellular and Molecular Biology Program, University of Michigan, Ann Arbor, MI, United States.
Craig J DobryDepartment of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI, United States.
Charles R EvansDepartment of Internal Medicine, University of Michigan, Ann Arbor, MI, United States.
Scott F LeiserDepartment of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI, United States.
University of Michigan–Ann Arbor · US

Funding

Research Education CoreP30AG024824 · NIA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Neil Alexander · 2004 to 2026
$29.2M
University of Michigan Center for Gastrointestinal ResearchP30DK034933 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI OWYANG, CHUNG · 1986 to 2021
$22.5M
Pilot and Feasibility (P and F) ProgramP30DK089503 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Joyce Lee · 2010 to 2026
$20.3M
Mechanisms of the cell non-autonomous dietary restriction pathwayR01AG059583 · NIA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI LEISER, SCOTT F · 2018 to 2022
$1.9M
Mechanisms of cell non-autonomous signaling through the hypoxic responseR01AG058717 · NIA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI LEISER, SCOTT F · 2019 to 2023
$1.6M
Novel approaches to study emerging roles of xenobiotic enzymesR21AG059117 · NIA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI LEISER, SCOTT F · 2018 to 2019
$429k
NIA NIH HHS P30 AG024824NIA NIH HHS R01 AG058717NIA NIH HHS R01 AG059583NIA NIH HHS R21 AG059117NIDDK NIH HHS P30 DK034933NIDDK NIH HHS P30 DK089503
6 · The paper itself

Abstract

Flavin-Containing Monooxygenases are conserved xenobiotic-detoxifying enzymes. Recent studies have revealed endogenous functions of FMOs in regulating longevity in

Indexed as

C. elegansFMOlongevitymammalian cellsmetabolismstress

Identifiers

PMID33644069
PMCPMC7907451
OpenAlexW3132838784

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.