Evidence map›Paper›PMID 33643930›Full record

ArticleFrontiers in cellular and infection microbiology2020

Charlotte-Eve S Short, Richard G Brown, Rachael Quinlan, Yun S Lee, Ann Smith, Julian R Marchesi, Robin Shattock, Phillip R Bennett, Graham P Taylor, David A MacIntyre

Open access · goldAbstract read
In one paragraph

Article in Frontiers in cellular and infection microbiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
2.7field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 22 citations in OpenAlex.

  1. Trial
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  8. Vaginal Microbiome and the Risk of Preterm Birth in Women Living With HIV: A Scoping Review.American journal of reproductive immunology (New York, N.Y. : 1989) · 2024
    Article
  9. Article
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  11. Article
  12. Article
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  14. Interactions between microbiota and cervical epithelial, immune, and mucus barrier.Frontiers in cellular and infection microbiology · 2023
    Review
  15. Review
  16. Article
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  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 6 institutions in 1 country.

Charlotte-Eve S ShortDepartment of Infectious Disease, Section of Virology, Imperial College London, London, United Kingdom.
Richard G BrownSt Mary's Hospital, Imperial College Healthcare NHS Trust, London, United Kingdom.
Rachael QuinlanDepartment of Infectious Disease, Section of Virology, Imperial College London, London, United Kingdom.
Yun S LeeDepartment of Metabolism, Digestion, and Reproduction, March of Dimes Prematurity Research Centre, Division of the Institute of Reproductive and Developmental Biology, Faculty of Medicine, Imperial College London, London, United Kingdom.
Ann SmithFaculty of Health and Applied Sciences, University West of England, Bristol, United Kingdom.
Julian R MarchesiDepartment of Metabolism, Digestion, and Reproduction, March of Dimes Prematurity Research Centre, Division of the Institute of Reproductive and Developmental Biology, Faculty of Medicine, Imperial College London, London, United Kingdom.
Robin ShattockDepartment of Infectious Disease, Section of Mucosal Infection and Immunity, Imperial College London, London, United Kingdom.
Phillip R BennettSt Mary's Hospital, Imperial College Healthcare NHS Trust, London, United Kingdom.
Graham P TaylorDepartment of Infectious Disease, Section of Virology, Imperial College London, London, United Kingdom.
David A MacIntyreDepartment of Metabolism, Digestion, and Reproduction, March of Dimes Prematurity Research Centre, Division of the Institute of Reproductive and Developmental Biology, Faculty of Medicine, Imperial College London, London, United Kingdom.
Imperial College London · GBSt Mary's Hospital · GBCardiff University · GBImperial College Healthcare NHS Trust · GBSt. Mary's Hospital · GBUniversity of the West of England · GB

Funding

Department of Health P45272Medical Research Council MR/L009226/1Wellcome TrustWellcome Trust WT/102757/Z/13/Z
6 · The paper itself

Abstract

Background: Pregnant women living with HIV-1 infection (PWLWH) have an elevated risk of preterm birth (PTB) of unknown aetiology, which remains after successful suppression of HIV. Women at high risk for HIV have a common bacterial profile which has been associated with poor birth outcomes. We set out to explore factors associated with gestational age at delivery of PWLWH in a UK population. Methods: Prospective study of PWLWH (n = 53) in whom the vaginal microbiota and cervicovaginal cytokine Findings: There was a high rate of PTB among PWLWH (12%). In the second trimester the vaginal microbiota was more diverse in PWLWH than in HUPW (Inverse Simpson Index, p = 0.0004 and Species Observed, p = 0.009). PWLWH had a lower prevalence of Interpretation: There is an association between local inflammation, vaginal dysbiosis and PTB in PWLWH. Understanding the potential of antiretroviral therapies to influence this cascade will be important to improve birth outcomes in this population.

Indexed as

HIV-1HIV InfectionsMicrobiotaPremature BirthCross-Sectional StudiesFemaleHumansInfant, NewbornInflammationLactobacillusPregnancyPregnant PeopleProspective StudiesVaginabacterial diversitycytokinesHIVinflammationLactobacillus sp. Gardnerella spp.microbiomepreterm

Identifiers

PMID33643930
PMCPMC7905210
OpenAlexW3128452648

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.