ArticleJournal of clinical & translational endocrinology2021
Malignancy rates in thyroid nodules classified as Bethesda categories III and IV; a subcontinent perspective.
Article in Journal of clinical & translational endocrinology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 24 citations in OpenAlex.
- The Diagnostic Performance of Afirma Genomic Sequencing Classifier in Black and Hispanic Patients With Indeterminate Thyroid Nodules.Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery · 2026Article
- Evolution of thyroid fine-needle aspiration biopsy performance over 15 years: implications for risk stratification in clinical practice.Archives of endocrinology and metabolism · 2026Article
- Performance of Seven-Gene Panel Testing for Risk Stratification of Thyroid Nodules with Indeterminate Cytology Results.International journal of molecular sciences · 2026Article
- Assessment of an innovative synthetic matrix for enhanced cell preservation: evaluating its clinical utility and impact on diagnostic precision in thyroid fine-needle aspiration cytology.BMC endocrine disorders · 2026Article
- Prevalence and predictors of malignancy in Bethesda III and IV thyroid nodules undergoing surgery.Frontiers in endocrinology · 2026Article
- Inside the Matrix: Integrated Cytology and Molecular Testing of Thyroid FNAC Samples Using a Commercial Synthetic 3D Scaffold.International journal of molecular sciences · 2025Article
- Clinical Outcomes of Patients With Bethesda III or IV Cytology on Fine Needle Aspiration of Thyroid Nodules-A Retrospective Study.Endocrinology, diabetes & metabolism · 2025Article
- Great Debate: Molecular Testing and Extent of Surgery in Well-Differentiated Thyroid Cancer.Annals of surgical oncology · 2025Article
- Clinical and molecular genetic analysis of cytologically uncertain thyroid nodules in patients with thyroid disease.Biomedical papers of the Medical Faculty of the University Palacky, Olomouc, Czechoslovakia · 2025Article
- Ultrasound radiomics and genomics improve the diagnosis of cytologically indeterminate thyroid nodules.Frontiers in endocrinology · 2025Review
- Association Between Triglyceride-Glucose Index and Malignant Risk in Thyroid Nodules: A Cross-Sectional Analysis.Journal of inflammation research · 2025Article
- Rates and Predictors of Malignancy in Bethesda III and IV Thyroid Nodules: A Prospective Study.Cureus · 2024Article
- Role of clinicopathologic and sonographic characteristics for the management of patients with cytological diagnosis of thyroid follicular neoplasm.Gland surgery · 2024Article
- Volume reduction rate of radiofrequency ablation in ≤ 2 cm Bethesda IV thyroid nodules.European radiology · 2024Observational
- Autoimmune Thyroid Disease and Differentiated Thyroid Carcinoma: A Review of the Mechanisms That Explain an Intriguing and Exciting Relationship.World journal of oncology · 2024Review
- Comparison of Fine-Needle Aspiration Cytopathology with Histopathological Examination of the Thyroid Gland in Patients Undergoing Elective Thyroid Surgery: Do We Still Need Fine-Needle Aspiration Cytopathology?Diagnostics (Basel, Switzerland) · 2024Article
- Ultrasonographic predictors of thyroid cancer in Bethesda III and IV thyroid nodules.Frontiers in endocrinology · 2024Article
- Impact of ultrasound elastography in evaluating Bethesda category IV thyroid nodules with histopathological correlation.Frontiers in endocrinology · 2024Article
- Managing Bethesda IV thyroid nodules in an iodine-deficient population.Gland surgery · 2023Article
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundBethesda category III and IV thyroid nodules fall in the indeterminate risk of malignancy category. These nodules have been a relatively elusive entity to manage as previous studies have shown a wide variation in malignancy rates in different regions and institutions across the world. However, data from the subcontinent with regards to this is scarce. AIM AND
objectiveThis study aimed to determine the characteristics and malignancy rates of cytology proven Bethesda Category III and IV thyroid nodules and its association with clinical, histopathological and laboratory variables, in the regional population.
methodA retrospective search was performed on all patients with thyroid nodules who presented to this hospital, from January 2011 to September 2018. Patients who had cytology proven Bethesda category III and IV thyroid nodules that underwent surgery were included in the study.
resultsMalignancy in Bethesda Category III and Bethesda Category IV thyroid nodules was 29.6% and 47.1%, respectively. There was no significant association determined between malignancy rate and various clinical, histopathological, and radiological characteristics.
conclusionThe malignancy rates in Bethesda category III and IV thyroid nodules in this study are significantly higher than that initially suggested by the Bethesda consensus publication but is comparable to international data present.
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