Evidence map›Paper›PMID 33643791›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2021

Nidogen-1 Mitigates Ischemia and Promotes Tissue Survival and Regeneration.

Aline Zbinden, Shannon L Layland, Max Urbanczyk, Daniel A Carvajal Berrio, Julia Marzi, Monika Zauner, Anne Hammerschmidt, Eva M Brauchle, Katrin Sudrow, Simon Fink and 11 more

Abstract read
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed.

  1. Article
  2. Glycocalyx and basal lamina in neurological disorders.Matrix biology : journal of the International Society for Matrix Biology · 2026
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors.

Aline ZbindenDepartment of Bioengineering Eberhard Karls University Tübingen Tübingen 72076 Germany.
Shannon L LaylandDepartment of Bioengineering Eberhard Karls University Tübingen Tübingen 72076 Germany.
Max UrbanczykDepartment of Bioengineering Eberhard Karls University Tübingen Tübingen 72076 Germany.
Daniel A Carvajal BerrioDepartment of Bioengineering Eberhard Karls University Tübingen Tübingen 72076 Germany.
Julia MarziDepartment of Bioengineering Eberhard Karls University Tübingen Tübingen 72076 Germany.
Monika ZaunerDepartment of Women's Health Research Institute for Women's Health Eberhard Karls University Tübingen Tübingen 72076 Germany.
Anne HammerschmidtDepartment of Women's Health Research Institute for Women's Health Eberhard Karls University Tübingen Tübingen 72076 Germany.
Eva M BrauchleDepartment of Women's Health Research Institute for Women's Health Eberhard Karls University Tübingen Tübingen 72076 Germany.
Katrin SudrowInstitute of Medical Immunology Charité Universitätsmedizin Berlin corporate member of Freie Universität Berlin Humboldt-Universität zu Berlin Berlin 10117 Germany.
Simon FinkNMI Natural and Medical Sciences Institute at the University of Tübingen Reutlingen 72770 Germany.
Markus TemplinNMI Natural and Medical Sciences Institute at the University of Tübingen Reutlingen 72770 Germany.
Simone LiebscherDepartment of Bioengineering Eberhard Karls University Tübingen Tübingen 72076 Germany.
Gerd KleinCenter for Medical Research Department of Medicine II Eberhard Karls University Tübingen Tübingen 72076 Germany.
Arjun DebDepartment of Molecular Cell and Developmental Biology UCLA Los Angeles CA 90095 USA.
Garry P DuffyAnatomy and Regenerative Medicine Institute School of Medicine College of Medicine Nursing and Health Sciences National University of Ireland Galway Galway H91TK33 Ireland.
Gay M CrooksEli and Edythe Broad Stem Cell Research Center UCLA Los Angeles CA 90095 USA.
Johannes A EbleInstitute of Physiological Chemistry and Pathobiochemistry University of Münster Münster 48149 Germany.
Hanna K A MikkolaDepartment of Molecular Cell and Developmental Biology UCLA Los Angeles CA 90095 USA.
Ali NsairEli and Edythe Broad Stem Cell Research Center UCLA Los Angeles CA 90095 USA.
Martina SeifertInstitute of Medical Immunology Charité Universitätsmedizin Berlin corporate member of Freie Universität Berlin Humboldt-Universität zu Berlin Berlin 10117 Germany.
Katja Schenke-LaylandDepartment of Bioengineering Eberhard Karls University Tübingen Tübingen 72076 Germany.ORCID https://orcid.org/0000-0001-8066-5157

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Ischemia impacts multiple organ systems and is the major cause of morbidity and mortality in the developed world. Ischemia disrupts tissue homeostasis, driving cell death, and damages tissue structure integrity. Strategies to heal organs, like the infarcted heart, or to replace cells, as done in pancreatic islet

Indexed as

diabetesischemiamyocardial infarctionnidogen‐1pancreatic β‐cells

Identifiers

PMID33643791
PMCPMC7887579

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.