ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2021
Ultrabright NIR-II Emissive Polymer Dots for Metastatic Ovarian Cancer Detection.
Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 64 citations in OpenAlex.
- A folate receptor-targeted NIR-II probe improves intraoperative imaging and surgery of metastatic ovarian cancer.Science advances · 2026Article
- Molecular Gold Nanoclusters for Advanced NIR-II Bioimaging and Therapy.Chemical reviews · 2025Review
- Modern Emerging Biosensing Methodologies for the Early Diagnosis and Screening of Ovarian Cancer.Biosensors · 2025Review
- Luminescence Fingerprint of Intracellular NIR-II Gold Nanocluster Transformation: Implications for Sensing and Imaging.ACS nano · 2025Article
- A planar electronic acceptor motif contributing to NIR-II AIEgen with combined imaging and therapeutic applications.Chemical science · 2024Article
- A pH-responsive nanoplatform with dual-modality imaging for enhanced cancer phototherapy and diagnosis of lung metastasis.Journal of nanobiotechnology · 2024Article
- Indocyanine Green (ICG) Fluorescence Is Dependent on Monomer with Planar and Twisted Structures and Inhibited by H-Aggregation.International journal of molecular sciences · 2023Article
- Functional biomaterials for the diagnosis and treatment of peritoneal surface malignancies.Smart medicine · 2023Review
- NIR-II Fluorescence Imaging for the Detection and Resection of Cancerous Foci and Lymph Nodes in Early-Stage Orthotopic and Advanced-Stage Metastatic Ovarian Cancer Models.ACS applied materials & interfaces · 2023Article
- Tracking tumor heterogeneity and progression with near-infrared II fluorophores.Exploration (Beijing, China) · 2023Review
- Recent Advances of NIR-II Emissive Semiconducting Polymer Dots for In Vivo Tumor Fluorescence Imaging and Theranostics.Biosensors · 2022Review
- Updates on fluorescent probes and open-field imaging methods for fluorescence-guided cytoreductive surgery for epithelial ovarian cancer: A review.BJOG : an international journal of obstetrics and gynaecology · 2022Review
- The Role of Optical Imaging in Translational Nanomedicine.Journal of functional biomaterials · 2022Review
- Recent advances in ultrasound-controlled fluorescence technology for deep tissue optical imaging.Journal of pharmaceutical analysis · 2022Review
- Nanoparticulate Photoluminescent Probes for Bioimaging: Small Molecules and Polymers.International journal of molecular sciences · 2022Review
- Magnetic and near-infrared-II fluorescence Au-Gd nanoclusters for imaging-guided sensitization of tumor radiotherapy.Nanoscale advances · 2022Article
- Near-infrared-II ratiometric fluorescence probes for non-invasive detection and precise navigation surgery of metastatic sentinel lymph nodes.Theranostics · 2022Article
- The Development of Nanoparticles for the Detection and Imaging of Ovarian Cancers.Biomedicines · 2021Review
- Ultrabright NIR-II Emissive Polymer Dots for Metastatic Ovarian Cancer Detection.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2021Article
- Organic Fluorophores for 1064 nm Excited NIR-II Fluorescence Imaging.Frontiers in chemistry · 2021Review
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Intraoperative diagnosis of metastatic tumors is of significant importance to the treatment of ovarian cancer. NIR-II fluorescence imaging holds great promise for facile detection of tumor in situ with high sensitivity and resolution. Herein, a kind of NIR-II fluorescent polymer dots (NIR-II Pdots) with high brightness is developed for real-time detection of metastatic ovarian cancer via NIR-II fluorescence imaging. The NIR-II Pdots are constructed via the self-assembly of NIR-II emissive aggregation induced emission luminogens (NIR-II AIEgens) and poly (styrene)-graft-poly(ethylene glycol) in water. Such NIR-II Pdots show very high fluorophore contents of nearly 30% and high quantum yield of 5.4% at emission maximum near 1020 nm. Further modification of the NIR-II Pdots with targeting peptides yields NIR-II Pdots-GnRH, which can afford enhanced affinity of NIR-II Pdots to ovarian cancer. Upon intravenous injection of the NIR-II Pdots, whole-body organs and vessels, peritoneal and lymphatic metastases of ovarian cancer are clearly visualized by NIR-II fluorescence imaging. Under the guidance of NIR-II fluorescence imaging, the metastatic foci with the diameter down to ≈2 mm can be facilely eliminated. The results indicate preclinical potential value of the NIR-II Pdots for metastatic ovarian cancer detection.
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