Evidence map›Paper›PMID 33643653›Full record

ArticleClinical & translational immunology2021

Tumor-associated neutrophils (TANs) in human carcinoma-draining lymph nodes: a novel TAN compartment.

Silvia Lonardi, Francesco Missale, Stefano Calza, Mattia Bugatti, Raffaella Vescovi, Bresciani Debora, Ravindra Uppaluri, Ann Marie Egloff, Davide Mattavelli, Davide Lombardi and 8 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Clinical & translational immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 2 pooled it
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 2 syntheses or guidelines pooled it, 25 citations in OpenAlex.

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  5. Neutrophils in tumor- and inflammation-induced lymphangiogenesis.International journal of biological sciences · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 7 institutions in 3 countries.

Silvia LonardiSection of Pathology Department of Molecular and Translational Medicine University of Brescia Brescia Italy.ORCID https://orcid.org/0000-0003-0307-4163
Francesco MissaleUnit of Otorhinolaryngology - Head and Neck Surgery Department of Surgical Specialties Radiological Sciences, and Public Health University of Brescia Brescia Italy.
Stefano CalzaUnit of Biostatistics Department of Molecular and Translational Medicine University of Brescia Brescia Italy.
Mattia BugattiSection of Pathology Department of Molecular and Translational Medicine University of Brescia Brescia Italy.
Raffaella VescoviSection of Pathology Department of Molecular and Translational Medicine University of Brescia Brescia Italy.
Bresciani DeboraSection of Pathology Department of Molecular and Translational Medicine University of Brescia Brescia Italy.
Ravindra UppaluriDepartment of Surgery/Otolaryngology Brigham and Women's Hospital and Dana-Farber Cancer Institute and Harvard Medical School Boston MA USA.
Ann Marie EgloffDepartment of Surgery/Otolaryngology Brigham and Women's Hospital and Dana-Farber Cancer Institute and Harvard Medical School Boston MA USA.
Davide MattavelliUnit of Otorhinolaryngology - Head and Neck Surgery Department of Surgical Specialties Radiological Sciences, and Public Health University of Brescia Brescia Italy.
Davide LombardiASST- Spedali Civili di Brescia Brescia Italy.
Luisa Benerini GattaSection of Pathology Department of Molecular and Translational Medicine University of Brescia Brescia Italy.
Olivia MariniSection of General Pathology Department of Medicine University of Verona Verona Italy.
Nicola TamassiaSection of General Pathology Department of Medicine University of Verona Verona Italy.
Elisa GardimanSection of General Pathology Department of Medicine University of Verona Verona Italy.
Marco A CassatellaSection of General Pathology Department of Medicine University of Verona Verona Italy.
Patrizia ScapiniSection of General Pathology Department of Medicine University of Verona Verona Italy.
Piero NicolaiASST- Spedali Civili di Brescia Brescia Italy.
William VermiSection of Pathology Department of Molecular and Translational Medicine University of Brescia Brescia Italy.
Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia · ITUniversity of Verona · ITBrigham and Women's Hospital · USUniversity of Brescia · ITKarolinska Institutet · SEOspedale Policlinico San Martino · ITWashington University in St. Louis · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesThe role of tumor-associated neutrophils (TANs) in the nodal spread of cancer cells remains unexplored. The present study evaluates the occurrence and clinical significance of human nodal TANs.

methodsThe relevance, derivation, phenotype and interactions of nodal TANs were explored

resultsThe pan-carcinoma screening identified a consistent infiltration (59%) of CD66b

conclusionOur findings are consistent with a novel pro-tumoral TAN compartment that may promote nodal spread

Indexed as

carcinomaepithelial‐to‐mesenchymal transitionlymph nodesmetastasistumor‐associated neutrophils

Identifiers

PMID33643653
PMCPMC7886597
OpenAlexW3132165913

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.