ArticlePain research & management2021
Central Sensitization in Neurological, Psychiatric, and Pain Disorders: A Multicenter Case-Controlled Study.
Article in Pain research & management, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed.
- Factors affecting central sensitization inventory score before surgery for distal radius fractures.Experimental and therapeutic medicine · 2026Article
- Central Sensitization and Neuropathic Pain in Hemiplegic Shoulder Pain: A Cross-Sectional Study.Medeniyet medical journal · 2026Article
- Effect of co-morbid anxiety and depression history on multidomain concussion clinical outcomes and recovery time.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026Article
- The Relationship Between Pain and Depression in Fibromyalgia: Structural Equation Modeling and Network Analysis.International journal of environmental research and public health · 2026Article
- Expanding the Spectrum of Central Sensitivity Syndrome: Integrating Otologic Migraine as Otologic Central Sensitivity Syndrome.Brain sciences · 2026Review
- Uncovering the Latent Components of Physical Performance in Professional Soccer: Evidence from the Turkish First Division.Journal of functional morphology and kinesiology · 2025Article
- The pathophysiologic mechanisms of spinal manipulative therapy in the management of chronic musculoskeletal pain.The Journal of the Canadian Chiropractic Association · 2025Article
- Major depressive disorder in fibromyalgia: novel insights from resting-state functional connectivity analysis.The Korean journal of pain · 2025Article
- Non-Cyclical Mastalgia as a Central Sensitization Component: Implications for Multidisciplinary Treatment Approaches.Brain and behavior · 2025Article
- Relationship between low back pain and sleep quality.Sleep and biological rhythms · 2025Article
- Milnacipran and Vanillin Alleviate Fibromyalgia-Associated Depression in Reserpine-Induced Rat Model: Role of Wnt/β-Catenin Signaling.Molecular neurobiology · 2025Article
- Delayed onset muscle soreness in neurological rehabilitation: an overlooked challenge.Acta neurologica Belgica · 2025Article
- The Influence of Preoperative Central Sensitization on the Postoperative Prognosis of Pilon Fractures: A Retrospective Study.Journal of pain research · 2025Article
- Efficacy of galcanezumab in migraine central sensitizationScientific reports · 2024Article
- The Impact of COVID-19 Health Measures on Adults With Multiple Chemical Sensitivity: Cross-Sectional Study.JMIR formative research · 2024Article
- Psycho-Neuroendocrinology in the Rehabilitation Field: Focus on the Complex Interplay between Stress and Pain.Medicina (Kaunas, Lithuania) · 2024Review
- Depressive Symptoms in Patients with Fibromyalgia: Current Evidence and Preventive Approaches.Journal of clinical medicine · 2023Article
- Exploratory Study on Central Sensitization and Bioelectrical Activity of the Selected Masticatory Muscles in Subjects with Myopia.International journal of environmental research and public health · 2023Article
- Central Sensitization in Patients with Chronic Pain Secondary to Carpal Tunnel Syndrome and Determinants.Journal of pain research · 2023Article
- Spontaneous pain as a challenge of research and management in chronic pain.Medical review (2021) · 2022Review
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: The role of central sensitization in refractory pain-related diseases has not yet been clarified. Methods: We performed a multicenter case-controlled study including 551 patients with various neurological, psychological, and pain disorders and 5,188 healthy controls to investigate the impact of central sensitization in these patients. Symptoms related to central sensitization syndrome (CSS) were assessed by the Central Sensitization Inventory (CSI) parts A and B. Patients were categorized into 5 groups based on CSI-A scores from subclinical to extreme. The Brief Pain Inventory (BPI), addressing pain severity and pain interference with daily activities, and the Patient Health Questionnaire (PHQ)-9, assessing depressive symptoms, were also administered. Results: CSI-A scores and CSI-B disease numbers were significantly greater in patients than in controls ( Conclusions: Our findings suggest that CSS may participate in these conditions as common pathophysiology.
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