Evidence map›Paper›PMID 33643450›Full record

ArticleNanobiomedicine

Green synthesis of gold nanoparticles using Acai berry and Elderberry extracts and investigation of their effect on prostate and pancreatic cancer cells.

Nicole Remaliah Samantha Sibuyi, Velaphi Clement Thipe, Kiandokht Panjtan-Amiri, Mervin Meyer, Kattesh V Katti

Open access · bronzeAbstract read
In one paragraph

Article in Nanobiomedicine. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
4.1field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 67 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Nicole Remaliah Samantha SibuyiDepartment of Science and Technology, Mintek Nanotechnology Innovation Centre (DST/Mintek NIC), Biolabels Node, Department of Biotechnology, University of Western Cape, Cape Town, South Africa.ORCID https://orcid.org/0000-0001-7175-5388
Velaphi Clement ThipeInstitute of Green Nanotechnology and Cancer Nanotechnology, Department of Radiology, Missouri University, Columbia, USA.
Kiandokht Panjtan-AmiriInstitute of Green Nanotechnology and Cancer Nanotechnology, Department of Radiology, Missouri University, Columbia, USA.
Mervin MeyerDepartment of Science and Technology, Mintek Nanotechnology Innovation Centre (DST/Mintek NIC), Biolabels Node, Department of Biotechnology, University of Western Cape, Cape Town, South Africa.
Kattesh V KattiInstitute of Green Nanotechnology and Cancer Nanotechnology, Department of Radiology, Missouri University, Columbia, USA.
Mintek · ZA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Green nanotechnology has drawn major attention because of its ecofriendly and economical biosynthetic protocols. Synthesis of gold nanoparticles (AuNPs) using plant secondary metabolites is considered as a safer and cheaper option. Plants contain phytochemicals that has been used traditionally for treatment of various diseases, and proved to be non-toxic to healthy tissues. These phytochemicals play an important role in bio-reduction processes as reducing and stabilizing agents, and renders NPs selective toxicity towards diseased tissues. The study reports on the synthesis of AuNPs using Acai berry (AB) and Elderberry (EB) extracts and their anti-cancer properties. Formation of berry-AuNPs was confirmed through measurement of physico-chemical properties. The stability of the AuNPs was tested in biocompatible solutions. Anti-cancer activity of berry extracts and AuNPs was evaluated on the prostate (PC-3) and pancreatic (Panc-1) cancer cells. The berry extracts did not show toxicity to the cells, except for AB extracts on PC-3 cells at higher concentrations. The berry-AuNPs showed potential anti-cancer activities, and these effects could be further exploited for treatment of both the prostate and pancreatic cancers. Further studies are required to study the NP mechanism of action and specificity, as well as identify the phytochemicals involved in the synthesis of AuNPs.

Indexed as

Acai berryanti-cancer propertieselderberrygold nanoparticlesgreen nanotechnology

Identifiers

PMID33643450
PMCPMC7894693
OpenAlexW3132995101

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.