Evidence map›Paper›PMID 33643314›Full record

ArticleFrontiers in immunology2021

Downregulated Serum Exosomal miR-451a Expression Correlates With Renal Damage and Its Intercellular Communication Role in Systemic Lupus Erythematosus.

Lina Tan, Ming Zhao, Haijing Wu, Yuezhong Zhang, Xiaoliang Tong, Lihua Gao, Lu Zhou, Qianjin Lu, Jinrong Zeng

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
39citing papers in PubMed, 3 pooled it
3.1field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

39 citing papers in PubMed, 3 syntheses or guidelines pooled it, 54 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
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  4. Article
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  6. Article
  7. Plasma Exosomal LncRNA XIST Impairs CD4Journal of inflammation research · 2026
    Article
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  11. A Novel Role for Coilin in Vertebrate Innate Immunity.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2025
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Lina TanDepartment of Dermatology, Third Xiangya Hospital, Central South University, Changsha, China.
Ming ZhaoDepartment of Dermatology, Second Xiangya Hospital, Central South University, Changsha, China.
Haijing WuDepartment of Dermatology, Second Xiangya Hospital, Central South University, Changsha, China.
Yuezhong ZhangXiangya School of Medicine, Central South University, Changsha, China.
Xiaoliang TongDepartment of Dermatology, Third Xiangya Hospital, Central South University, Changsha, China.
Lihua GaoDepartment of Dermatology, Third Xiangya Hospital, Central South University, Changsha, China.
Lu ZhouDepartment of Dermatology, Third Xiangya Hospital, Central South University, Changsha, China.
Qianjin LuDepartment of Dermatology, Second Xiangya Hospital, Central South University, Changsha, China.
Jinrong ZengDepartment of Dermatology, Third Xiangya Hospital, Central South University, Changsha, China.
Central South University · CNSecond Xiangya Hospital of Central South University · CNThird Xiangya Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Systemic lupus erythematosus (SLE) is a multi-system autoimmune disease characterized by continuous inflammation and the production of autoantibodies. Exosomes, acting as a critical tool for communication between cells, are involved in the pathogenesis of SLE, particularly in inflammation and immune imbalance. In this study, we aimed to extract and confirm the pro-inflammatory effect of serum exosomes in SLE. Then, we attempted to find differentially expressed exosomal microRNAs in the serum of healthy subjects and SLE patients

Indexed as

Cell CommunicationAdultDown-RegulationExosomesFemaleHumansKidneyLupus Erythematosus, SystemicLupus NephritisMaleMicroRNAsYoung AdultMicroRNAsMIRN451 microRNA, humanexosomemicroRNA-451arenal damageserumSLE

Identifiers

PMID33643314
PMCPMC7906989
OpenAlexW3132161478

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.