Evidence map›Paper›PMID 33643306›Full record

ArticleFrontiers in immunology2020

Human IgA-Expressing Bone Marrow Plasma Cells Characteristically Upregulate Programmed Cell Death Protein-1 Upon B Cell Receptor Stimulation.

Annika Wiedemann, Marie Lettau, Ina Wirries, Annemarie Jungmann, Abdulrahman Salhab, Gilles Gasparoni, Henrik E Mei, Carsten Perka, Jörn Walter, Andreas Radbruch and 2 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.0field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 13 citations in OpenAlex.

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  6. B cells defined by immunoglobulin isotypes.Clinical and experimental immunology · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 1 country.

Annika WiedemannDepartment of Rheumatology and Clinical Immunology, Charité Universitätsmedizin Berlin, Berlin, Germany.
Marie LettauDepartment of Rheumatology and Clinical Immunology, Charité Universitätsmedizin Berlin, Berlin, Germany.
Ina WirriesDepartment of Rheumatology and Clinical Immunology, Charité Universitätsmedizin Berlin, Berlin, Germany.
Annemarie JungmannDepartment of Genetics and Epigenetics, Saarland University, Saarbrücken, Germany.
Abdulrahman SalhabDepartment of Genetics and Epigenetics, Saarland University, Saarbrücken, Germany.
Gilles GasparoniDepartment of Genetics and Epigenetics, Saarland University, Saarbrücken, Germany.
Henrik E MeiGerman Rheumatism Research Center Berlin (DRFZ), Berlin, Germany.
Carsten PerkaDepartment of Orthopedics, Charité Universitätsmedizin Berlin, Center for Musculoskeletal Surgery, Berlin, Germany.
Jörn WalterDepartment of Genetics and Epigenetics, Saarland University, Saarbrücken, Germany.
Andreas RadbruchGerman Rheumatism Research Center Berlin (DRFZ), Berlin, Germany.
Andreia C LinoDepartment of Rheumatology and Clinical Immunology, Charité Universitätsmedizin Berlin, Berlin, Germany.
Thomas DörnerDepartment of Rheumatology and Clinical Immunology, Charité Universitätsmedizin Berlin, Berlin, Germany.
Charité - Universitätsmedizin Berlin · DESaarland University · DEGerman Rheumatism Research Centre · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The functions of bone marrow plasma cells (BMPC) beyond antibody production are not fully elucidated and distinct subsets of BMPC suggest potential different functions. Phenotypic differences were identified for human BMPC depending on CD19 expression. Since CD19 is a co-stimulatory molecule of the B-cell-receptor (BCR), and IgA

Indexed as

AdultAgedAged, 80 and overBone Marrow CellsFemaleHumansImmunoglobulin AMaleMiddle AgedPlasma CellsProgrammed Cell Death 1 ReceptorReceptors, Antigen, B-CellUp-RegulationImmunoglobulin APDCD1 protein, humanProgrammed Cell Death 1 ReceptorReceptors, Antigen, B-CellB cell receptorB cellsCD19human bone marrowIgAplasma cellssignaling

Identifiers

PMID33643306
PMCPMC7907642
OpenAlexW3133266491

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.